Azithromycin and Joint stiffness - a phase IV clinical study of FDA data

Summary:

Joint stiffness is reported as a side effect among people who take Azithromycin (azithromycin), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Prednisone, and have Rheumatoid arthritis.

The phase IV clinical study analyzes which people have Joint stiffness when taking Azithromycin. It is created by eHealthMe based on reports of 38,326 people who have side effects when taking Azithromycin from the FDA, and is updated regularly.

What is Azithromycin?

Azithromycin has active ingredients of azithromycin. It is often used in sinusitis. eHealthMe is studying from 40,716 Azithromycin users. Check the latest studies of Azithromycin.

What is Joint stiffness?

Joint stiffness is found to be associated with 1,301 drugs and 1,340 conditions by eHealthMe. Check the latest studies of Joint stiffness.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 29, 2026

38,326 people reported to have side effects when taking Azithromycin.
Among them, 81 people (0.21%) have Joint stiffness.

Could Azithromycin cause Joint stiffness?

Among these 81 people:

How long have people been on Azithromycin when they have Joint stiffness? *

What is the gender of people who have Joint stiffness when taking Azithromycin? *

female: 73.75 %
male: 26.25 %

What is the age of people who have Joint stiffness when taking Azithromycin? *

What are other drugs people take besides Azithromycin? *

Prednisone: 43 people, 53.09%
Simvastatin: 34 people, 41.98%
Fenofibrate: 33 people, 40.74%
Hydrochlorothiazide: 33 people, 40.74%
Atenolol: 33 people, 40.74%
Ativan: 33 people, 40.74%
Irbesartan: 32 people, 39.51%
Ezetimibe: 32 people, 39.51%
Actemra: 32 people, 39.51%
Dicyclomine Hydrochloride: 32 people, 39.51%

What are other side effects people have besides Joint stiffness? *

Joint Pain: 55 people, 67.90%
Pain In Extremity: 51 people, 62.96%
Joint Swelling: 43 people, 53.09%
Cough: 43 people, 53.09%
Stress And Anxiety: 42 people, 51.85%
Pain: 42 people, 51.85%
Chest Pain: 42 people, 51.85%
Musculoskeletal Stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves): 41 people, 50.62%
Oxygen Saturation Decreased: 40 people, 49.38%
High Blood Pressure: 39 people, 48.15%

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 41 people, 50.62%
Hiatal Hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm): 32 people, 39.51%
Lower Respiratory Tract Infection: 28 people, 34.57%
Asthma: 5 people, 6.17%
High Blood Pressure: 5 people, 6.17%
Rashes (redness): 5 people, 6.17%
Constipation: 4 people, 4.94%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 3 people, 3.70%
Colitis (inflammation of colon): 3 people, 3.70%
Drowsiness: 3 people, 3.70%

* Approximation only. Some reports may have incomplete information.

Do you take Azithromycin and have Joint stiffness?

- Check whether Joint stiffness is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Azithromycin:

Azithromycin (40,716 reports)

Joint stiffness treatments and more:

Joint stiffness (33,165 reports)

Browse all side effects of Azithromycin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Joint stiffness:

Joint stiffness (1,301 drugs)

Browse all the conditions that are associated with Joint stiffness:

Joint stiffness (1,340 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on azithromycin (the active ingredients of Azithromycin) and Azithromycin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.