Azulfidine and Joint instability - a phase IV clinical study of FDA data

Summary:

Joint instability is reported as a side effect among people who take Azulfidine (sulfasalazine), especially for people who are female, 30-39 old, have been taking the drug for 1 - 6 months also take Methotrexate, and have Arthritis.

The phase IV clinical study analyzes which people have Joint instability when taking Azulfidine. It is created by eHealthMe based on reports of 7,893 people who have side effects when taking Azulfidine from the FDA, and is updated regularly.

What is Azulfidine?

Azulfidine has active ingredients of sulfasalazine. It is often used in rheumatoid arthritis. eHealthMe is studying from 7,997 Azulfidine users. Check the latest studies of Azulfidine.

What is Joint instability?

Joint instability (a condition in which the joints aren't sufficiently supported) is found to be associated with 230 drugs and 371 conditions by eHealthMe. Check the latest studies of Joint instability.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 30, 2026

7,893 people reported to have side effects when taking Azulfidine.
Among them, 16 people (0.2%) have Joint instability.

Could Azulfidine cause Joint instability?

Among these 16 people:

How long have people been on Azulfidine when they have Joint instability? *

What is the gender of people who have Joint instability when taking Azulfidine? *

female: 87.5 %
male: 12.5 %

What is the age of people who have Joint instability when taking Azulfidine? *

What are other drugs people take besides Azulfidine? *

What are other side effects people have besides Joint instability? *

Fatigue (feeling of tiredness): 15 people, 93.75%
Gait Disturbance: 15 people, 93.75%
Genital Rash (rash on sex organ): 14 people, 87.50%
Dizziness: 14 people, 87.50%
Mechanical Urticaria (urticaria is triggered by mechanical shearing forces e.g. stroking or scratching the skin): 14 people, 87.50%
Meniscus Lesion (lesion of a crescent-shaped piece of cartilage between the femur and the tibia): 14 people, 87.50%
Menopause (end of monthly cycles in women): 14 people, 87.50%
Mononeuropathy (a type of damage to nerves outside the brain and spinal cord): 14 people, 87.50%
Morton's Neuroma (a nerve tumour non cancer that affects one of the nerves that run between the long bones (metatarsals) in the foot): 14 people, 87.50%
Cyst (a closed sac): 14 people, 87.50%

What are the existing conditions these people have? *

Arthritis (form of joint disorder that involves inflammation of one or more joints): 14 people, 87.50%
Pain: 12 people, 75.00%
Hypersensitivity: 12 people, 75.00%
High Blood Cholesterol: 12 people, 75.00%
Headache (pain in head): 12 people, 75.00%
Gastric Ulcer (stomach ulcer): 12 people, 75.00%
Fibromyalgia (a long-term condition which causes pain all over the body): 12 people, 75.00%
Cardiac Disorder: 7 people, 43.75%
Herpes Virus Infection: 6 people, 37.50%
Torticollis (a twisted neck in which the head is tipped to one side, while the chin is turned to the other): 4 people, 25.00%

* Approximation only. Some reports may have incomplete information.

Do you take Azulfidine and have Joint instability?

- Check whether Joint instability is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Azulfidine:

Azulfidine (7,997 reports)

Browse all side effects of Azulfidine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Joint instability:

Joint instability (230 drugs)

Browse all the conditions that are associated with Joint instability:

Joint instability (371 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on sulfasalazine (the active ingredients of Azulfidine) and Azulfidine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.