B12 and Hyperkeratosis - a phase IV clinical study of FDA data

Summary:

Hyperkeratosis is reported as a side effect among people who take B12 (cobalamin), especially for people who are female, 60+ old, have been taking the drug for 1 - 6 months also take Calcium, and have Rheumatoid arthritis.

The phase IV clinical study analyzes which people have Hyperkeratosis when taking B12. It is created by eHealthMe based on reports of 119,647 people who have side effects when taking B12 from the FDA, and is updated regularly.

What is B12?

B12 has active ingredients of cobalamin. It is often used in vitamin b12 deficiency. eHealthMe is studying from 121,894 B12 users. Check the latest studies of B12.

What is Hyperkeratosis?

Hyperkeratosis (thickening of the outer layer of the skin) is found to be associated with 780 drugs and 771 conditions by eHealthMe. Check the latest studies of Hyperkeratosis.

On Jul, 19, 2026

119,647 people reported to have side effects when taking B12.
Among them, 80 people (0.07%) have Hyperkeratosis.

Among these 80 people:

How long have people been on B12 when they have Hyperkeratosis? *

What is the gender of people who have Hyperkeratosis when taking B12? *

female: 62.82 %
male: 37.18 %

What is the age of people who have Hyperkeratosis when taking B12? *

What are other drugs people take besides B12? *

What are other side effects people have besides Hyperkeratosis? *

Pain In Extremity: 34 people, 42.50%
Rashes (redness): 26 people, 32.50%
Diarrhea: 23 people, 28.75%
Weakness: 22 people, 27.50%
Weight Decreased: 22 people, 27.50%
Joint Pain: 21 people, 26.25%
High Blood Pressure: 18 people, 22.50%
Pain: 17 people, 21.25%
Skin Exfoliation (removal of the oldest dead skin cells): 16 people, 20.00%
Back Pain: 16 people, 20.00%

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 15 people, 18.75%
Renal Cell Carcinoma (a kidney cancer): 13 people, 16.25%
Pain: 12 people, 15.00%
High Blood Cholesterol: 11 people, 13.75%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 6 people, 7.50%
Depression: 6 people, 7.50%
Malignant Melanoma (skin cancer rises from melancytes): 5 people, 6.25%
Metastatic Renal Cell Carcinoma (spreadable kidney cell tumour): 5 people, 6.25%
Thyroid Diseases: 5 people, 6.25%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 5 people, 6.25%

* Approximation only. Some reports may have incomplete information.

Do you take B12 and have Hyperkeratosis?

- Check whether Hyperkeratosis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to B12:

B12 (121,894 reports)

Hyperkeratosis treatments and more:

Hyperkeratosis (8,056 reports)

Browse all side effects of B12:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hyperkeratosis:

Hyperkeratosis (780 drugs)

Browse all the conditions that are associated with Hyperkeratosis:

Hyperkeratosis (771 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on cobalamin (the active ingredients of B12) and B12 (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.