B12 and Hyperparathyroidism - a phase IV clinical study of FDA data

Summary:

Hyperparathyroidism is reported as a side effect among people who take B12 (cobalamin), especially for people who are female, 60+ old, also take Vitamin D, and have Iron deficiency anaemia.

The phase IV clinical study analyzes which people have Hyperparathyroidism when taking B12. It is created by eHealthMe based on reports of 119,647 people who have side effects when taking B12 from the FDA, and is updated regularly.

What is B12?

B12 has active ingredients of cobalamin. It is often used in vitamin b12 deficiency. eHealthMe is studying from 121,897 B12 users. Check the latest studies of B12.

What is Hyperparathyroidism?

Hyperparathyroidism (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium) is found to be associated with 449 drugs and 445 conditions by eHealthMe. Check the latest studies of Hyperparathyroidism.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

119,647 people reported to have side effects when taking B12.
Among them, 31 people (0.03%) have Hyperparathyroidism.

Among these 31 people:

What is the gender of people who have Hyperparathyroidism when taking B12? *

female: 90 %
male: 10 %

What is the age of people who have Hyperparathyroidism when taking B12? *

What are other drugs people take besides B12? *

What are other side effects people have besides Hyperparathyroidism? *

Hypercalcaemia (elevated calcium (ca+) level in the blood): 10 people, 32.26%
Pain: 10 people, 32.26%
Urinary Tract Infection: 9 people, 29.03%
Balance Disorder: 8 people, 25.81%
Confusional State: 8 people, 25.81%
Delirium (wild excitement): 7 people, 22.58%
Sepsis (a severe blood infection that can lead to organ failure and death): 7 people, 22.58%
Urinary Incontinence (inability to control the flow of urine and involuntary urination): 7 people, 22.58%
Depression: 7 people, 22.58%
Dehydration (dryness resulting from the removal of water): 7 people, 22.58%

What are the existing conditions these people have? *

Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 5 people, 16.13%
Iron Deficiency Anaemia: 5 people, 16.13%
Depression: 4 people, 12.90%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 3 people, 9.68%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 3 people, 9.68%
Osteoporosis (bones weak and more likely to break): 3 people, 9.68%
High Blood Cholesterol: 2 people, 6.45%
Nephrogenic Anaemia (anaemia due to kidney disease): 2 people, 6.45%
Neurogenic Bladder (the normal function of the bladder is to store and empty urine in a coordinated, controlled fashion): 2 people, 6.45%
Diabetes: 2 people, 6.45%

* Approximation only. Some reports may have incomplete information.

Do you take B12 and have Hyperparathyroidism?

- Check whether Hyperparathyroidism is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to B12:

B12 (121,897 reports)

Browse all side effects of B12:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hyperparathyroidism:

Hyperparathyroidism (449 drugs)

Browse all the conditions that are associated with Hyperparathyroidism:

Hyperparathyroidism (445 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on cobalamin (the active ingredients of B12) and B12 (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.