Baclofen and Bladder hypertrophy - a phase IV clinical study of FDA data

Summary:

Bladder hypertrophy is reported as a side effect among people who take Baclofen (baclofen), especially for people who are female, 50-59 old, also take Benadryl, and have Muscle spasticity.

The phase IV clinical study analyzes which people have Bladder hypertrophy when taking Baclofen. It is created by eHealthMe based on reports of 106,082 people who have side effects when taking Baclofen from the FDA, and is updated regularly.

What is Baclofen?

Baclofen has active ingredients of baclofen. It is often used in muscle spasms. eHealthMe is studying from 108,664 Baclofen users. Check the latest studies of Baclofen.

What is Bladder hypertrophy?

Bladder hypertrophy (bladder overgrowth- increase in cell size) is found to be associated with 102 drugs and 154 conditions by eHealthMe. Check the latest studies of Bladder hypertrophy.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 31, 2026

106,082 people reported to have side effects when taking Baclofen.
Among them, 22 people (0.02%) have Bladder hypertrophy.

Could Baclofen cause Bladder hypertrophy?

Among these 22 people:

What is the gender of people who have Bladder hypertrophy when taking Baclofen? *

female: 63.64 %
male: 36.36 %

What is the age of people who have Bladder hypertrophy when taking Baclofen? *

What are other drugs people take besides Baclofen? *

What are other side effects people have besides Bladder hypertrophy? *

Urinary Tract Infection: 15 people, 68.18%
Urinary Retention (the inability to completely or partially empty the bladder): 13 people, 59.09%
Pain: 11 people, 50.00%
Sciatica (a set of symptoms including pain caused by general compression or irritation of one of five spinal nerve roots of each sciatic nerve): 10 people, 45.45%
Pain In Extremity: 8 people, 36.36%
Fungal Infection: 8 people, 36.36%
Pressure Ulcer: 8 people, 36.36%
Constipation: 8 people, 36.36%
Joint Pain: 7 people, 31.82%
Multiple Sclerosis Relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 6 people, 27.27%

What are the existing conditions these people have? *

Muscle Spasticity (tight or stiff muscles and an inability to control those muscles): 9 people, 40.91%
Relapsing-Remitting Multiple Sclerosis (reoccurrence of an inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 8 people, 36.36%
Pain: 7 people, 31.82%
Fatigue (feeling of tiredness): 6 people, 27.27%
Pain In Extremity: 5 people, 22.73%
Joint Pain: 5 people, 22.73%
High Blood Pressure: 3 people, 13.64%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 3 people, 13.64%
Deep Venous Thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis): 2 people, 9.09%
Dyspnea (difficult or laboured breathing): 2 people, 9.09%

* Approximation only. Some reports may have incomplete information.

Do you take Baclofen and have Bladder hypertrophy?

- Check whether Bladder hypertrophy is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Baclofen:

Baclofen (108,664 reports)

Browse all side effects of Baclofen:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Bladder hypertrophy:

Bladder hypertrophy (102 drugs)

Browse all the conditions that are associated with Bladder hypertrophy:

Bladder hypertrophy (154 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on baclofen (the active ingredients of Baclofen) and Baclofen (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.