Bactrim and Aortic valve incompetence - a phase IV clinical study of FDA data

Summary:

Aortic valve incompetence is reported as a side effect among people who take Bactrim (sulfamethoxazole; trimethoprim), especially for people who are male, 60+ old, have been taking the drug for < 1 month also take Coumadin, and have Pain.

The phase IV clinical study analyzes which people have Aortic valve incompetence when taking Bactrim. It is created by eHealthMe based on reports of 86,509 people who have side effects when taking Bactrim from the FDA, and is updated regularly.

What is Bactrim?

Bactrim has active ingredients of sulfamethoxazole; trimethoprim. It is often used in urinary tract infection. eHealthMe is studying from 89,117 Bactrim users. Check the latest studies of Bactrim.

What is Aortic valve incompetence?

Aortic valve incompetence is found to be associated with 910 drugs and 881 conditions by eHealthMe. Check the latest studies of Aortic valve incompetence.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

86,509 people reported to have side effects when taking Bactrim.
Among them, 65 people (0.08%) have Aortic valve incompetence.

Could Bactrim cause Aortic valve incompetence?

Among these 65 people:

How long have people been on Bactrim when they have Aortic valve incompetence? *

What is the gender of people who have Aortic valve incompetence when taking Bactrim? *

female: 46.15 %
male: 53.85 %

What is the age of people who have Aortic valve incompetence when taking Bactrim? *

What are other drugs people take besides Bactrim? *

What are other side effects people have besides Aortic valve incompetence? *

Mitral Valve Incompetence (inefficient heart valve): 40 people, 61.54%
Tricuspid Valve Incompetence (inefficient heart valve): 24 people, 36.92%
Chest Pain: 21 people, 32.31%
Dyspnea (difficult or laboured breathing): 20 people, 30.77%
Nausea (feeling of having an urge to vomit): 15 people, 23.08%
Fatigue (feeling of tiredness): 15 people, 23.08%
Ejection Fraction Decreased (systolic heart failure): 13 people, 20.00%
Hypotension (abnormally low blood pressure): 12 people, 18.46%
Abdominal Pain: 12 people, 18.46%
High Blood Pressure: 11 people, 16.92%

What are the existing conditions these people have? *

Pain: 7 people, 10.77%
Hiv Infection: 5 people, 7.69%
Multiple Myeloma (cancer of the plasma cells): 5 people, 7.69%
Constipation: 5 people, 7.69%
Non-Hodgkin's Lymphoma (malignant (cancer) cells form in the lymph system): 4 people, 6.15%
High Blood Pressure: 4 people, 6.15%
Metastases To Bone (cancer spreads to bone): 3 people, 4.62%
Depression: 3 people, 4.62%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 2 people, 3.08%
Oesophageal Candidiasis (fungal infection of oesophagus): 2 people, 3.08%

* Approximation only. Some reports may have incomplete information.

Do you take Bactrim and have Aortic valve incompetence?

- Check whether Aortic valve incompetence is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Bactrim:

Bactrim (89,117 reports)

Aortic valve incompetence treatments and more:

Aortic valve incompetence (8,412 reports)

How severe was Aortic valve incompetence and when was it recovered:

Aortic valve incompetence in Bactrim

Expand to all the drugs that have ingredients of sulfamethoxazole; trimethoprim:

Aortic valve incompetence and drugs with ingredients of sulfamethoxazole; trimethoprim

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Bactrim:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Aortic valve incompetence:

Aortic valve incompetence (910 drugs)

Browse all the conditions that are associated with Aortic valve incompetence:

Aortic valve incompetence (881 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on sulfamethoxazole; trimethoprim (the active ingredients of Bactrim) and Bactrim (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.