Bactrim and Icterus - a phase IV clinical study of FDA data

Summary:

Icterus is reported as a side effect among people who take Bactrim (sulfamethoxazole; trimethoprim), especially for people who are male, 60+ old, have been taking the drug for < 1 month also take Paracetamol, and have Hiv infection.

The phase IV clinical study analyzes which people have Icterus when taking Bactrim. It is created by eHealthMe based on reports of 86,509 people who have side effects when taking Bactrim from the FDA, and is updated regularly.

What is Bactrim?

Bactrim has active ingredients of sulfamethoxazole; trimethoprim. It is often used in urinary tract infection. eHealthMe is studying from 89,114 Bactrim users. Check the latest studies of Bactrim.

What is Icterus?

Icterus (yellowish pigmentation of the skin) is found to be associated with 2,215 drugs and 2,985 conditions by eHealthMe. Check the latest studies of Icterus.

On Oct, 14, 2025

86,509 people reported to have side effects when taking Bactrim.
Among them, 423 people (0.49%) have Icterus.

Among these 423 people:

How long have people been on Bactrim when they have Icterus? *

What is the gender of people who have Icterus when taking Bactrim? *

female: 38.27 %
male: 61.73 %

What is the age of people who have Icterus when taking Bactrim? *

What are other drugs people take besides Bactrim? *

What are other side effects people have besides Icterus? *

Cholestasis (a condition where bile cannot flow from the liver to the duodenum): 80 people, 18.91%
Fever: 77 people, 18.20%
Fatigue (feeling of tiredness): 71 people, 16.78%
Nausea And Vomiting: 66 people, 15.60%
Blood Alkaline Phosphatase Increased: 64 people, 15.13%
Nausea (feeling of having an urge to vomit): 62 people, 14.66%
Thrombocytopenia (decrease of platelets in blood): 59 people, 13.95%
Diarrhea: 59 people, 13.95%
Blood Bilirubin Increased: 57 people, 13.48%
Abdominal Pain: 55 people, 13.00%

What are the existing conditions these people have? *

Hiv Infection: 75 people, 17.73%
Pain: 48 people, 11.35%
High Blood Pressure: 43 people, 10.17%
Anaemia (lack of blood): 37 people, 8.75%
Diabetes: 34 people, 8.04%
Calcium Deficiency (lack of calcium): 30 people, 7.09%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 30 people, 7.09%
Nephropathy (damage to or disease of a kidney): 30 people, 7.09%
Adenocarcinoma Pancreas (cancer of pancreas): 29 people, 6.86%
Nausea And Vomiting: 29 people, 6.86%

* Approximation only. Some reports may have incomplete information.

Do you take Bactrim and have Icterus?

- Check whether Icterus is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Bactrim:

Bactrim (89,114 reports)

Icterus treatments and more:

Icterus (33,621 reports)

How severe was Icterus and when was it recovered:

Icterus in Bactrim

Expand to all the drugs that have ingredients of sulfamethoxazole; trimethoprim:

Icterus and drugs with ingredients of sulfamethoxazole; trimethoprim (1,114 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Common Bactrim side effects:

Bactrim side effect: Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection) (4,107 reports)

Browse all side effects of Bactrim:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Common drugs associated with Icterus:

Browse all the drugs that are associated with Icterus:

Icterus (2,215 drugs)

Common conditions associated with Icterus:

Htn: 2,055 reports
Human immunodeficiency virus infection: 1,000 reports
Hiv test: 978 reports
Hepatitis c: 954 reports
Pain exacerbated: 856 reports
Pain relief: 832 reports
Depression: 830 reports
Diabetes: 676 reports
Diabetes mellitus non-insulin-dependent: 667 reports
Rheumatoid arthritis: 663 reports

Browse all the conditions that are associated with Icterus:

Icterus (2,985 conditions)

Drugs similar to Bactrim and Icterus :

How the study uses the data?

The study uses data from the FDA. It is based on sulfamethoxazole; trimethoprim (the active ingredients of Bactrim) and Bactrim (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.