Bactrim and Sinus node dysfunction - a phase IV clinical study of FDA data

Summary:

Sinus node dysfunction is reported as a side effect among people who take Bactrim (sulfamethoxazole; trimethoprim), especially for people who are female, 60+ old, have been taking the drug for 2 - 5 years also take Coumadin, and have Metastases to bone.

The phase IV clinical study analyzes which people have Sinus node dysfunction when taking Bactrim. It is created by eHealthMe based on reports of 86,509 people who have side effects when taking Bactrim from the FDA, and is updated regularly.

What is Bactrim?

Bactrim has active ingredients of sulfamethoxazole; trimethoprim. It is often used in urinary tract infection. eHealthMe is studying from 89,115 Bactrim users. Check the latest studies of Bactrim.

What is Sinus node dysfunction?

Sinus node dysfunction (a group of abnormal heart rhythms) is found to be associated with 1,245 drugs and 835 conditions by eHealthMe. Check the latest studies of Sinus node dysfunction.

On Oct, 11, 2025

86,509 people reported to have side effects when taking Bactrim.
Among them, 60 people (0.07%) have Sinus node dysfunction.

Could Bactrim cause Sinus node dysfunction?

Among these 60 people:

How long have people been on Bactrim when they have Sinus node dysfunction? *

What is the gender of people who have Sinus node dysfunction when taking Bactrim? *

female: 64.41 %
male: 35.59 %

What is the age of people who have Sinus node dysfunction when taking Bactrim? *

What are other drugs people take besides Bactrim? *

What are other side effects people have besides Sinus node dysfunction? *

Cardiac Failure Congestive: 27 people, 45.00%
Dizziness: 26 people, 43.33%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 25 people, 41.67%
Activities Of Daily Living Impaired: 22 people, 36.67%
Anaemia (lack of blood): 22 people, 36.67%
Injury: 22 people, 36.67%
Pain: 22 people, 36.67%
Confusional State: 22 people, 36.67%
Stress And Anxiety: 22 people, 36.67%
Osteomyelitis (infection of bone): 22 people, 36.67%

What are the existing conditions these people have? *

Metastases To Bone (cancer spreads to bone): 21 people, 35.00%
Pain: 17 people, 28.33%
Hiv Infection: 12 people, 20.00%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 9 people, 15.00%
High Blood Pressure: 6 people, 10.00%
Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection): 3 people, 5.00%
Muscle Spasms (muscle contraction): 3 people, 5.00%
Multiple Myeloma (cancer of the plasma cells): 3 people, 5.00%
Type 2 Diabetes: 2 people, 3.33%
Hypercoagulation (increased tendency for clotting of the blood): 2 people, 3.33%

* Approximation only. Some reports may have incomplete information.

Do you take Bactrim and have Sinus node dysfunction?

- Check whether Sinus node dysfunction is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Bactrim:

Bactrim (89,115 reports)

Sinus node dysfunction treatments and more:

Sinus node dysfunction (4,617 reports)

How severe was Sinus node dysfunction and when was it recovered:

Sinus node dysfunction in Bactrim

Expand to all the drugs that have ingredients of sulfamethoxazole; trimethoprim:

Sinus node dysfunction and drugs with ingredients of sulfamethoxazole; trimethoprim

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Bactrim:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Sinus node dysfunction:

Sinus node dysfunction (1,245 drugs)

Browse all the conditions that are associated with Sinus node dysfunction:

Sinus node dysfunction (835 conditions)

Drugs similar to Bactrim and Sinus node dysfunction :

How the study uses the data?

The study uses data from the FDA. It is based on sulfamethoxazole; trimethoprim (the active ingredients of Bactrim) and Bactrim (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.