Benlysta and Limb discomfort - a phase IV clinical study of FDA data

Summary:

Limb discomfort is reported as a side effect among people who take Benlysta (belimumab), especially for people who are female, 50-59 old, have been taking the drug for 1 - 2 years also take Plaquenil, and have Lupus nephritis.

The phase IV clinical study analyzes which people have Limb discomfort when taking Benlysta. It is created by eHealthMe based on reports of 23,452 people who have side effects when taking Benlysta from the FDA, and is updated regularly.

What is Benlysta?

Benlysta has active ingredients of belimumab. It is often used in systemic lupus erythematosus. eHealthMe is studying from 23,528 Benlysta users. Check the latest studies of Benlysta.

What is Limb discomfort?

Limb discomfort (discomfort in leg) is found to be associated with 1,293 drugs and 1,076 conditions by eHealthMe. Check the latest studies of Limb discomfort.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 25, 2026

23,452 people reported to have side effects when taking Benlysta.
Among them, 70 people (0.3%) have Limb discomfort.

Among these 70 people:

How long have people been on Benlysta when they have Limb discomfort? *

What is the gender of people who have Limb discomfort when taking Benlysta? *

female: 83.64 %
male: 16.36 %

What is the age of people who have Limb discomfort when taking Benlysta? *

What are other drugs people take besides Benlysta? *

Plaquenil: 14 people, 20.00%
Methotrexate: 13 people, 18.57%
Vitamin D: 13 people, 18.57%
Clopidogrel: 12 people, 17.14%
Cellcept: 8 people, 11.43%
Carvedilol: 8 people, 11.43%
Prednisone: 7 people, 10.00%
Benadryl: 6 people, 8.57%
Hydroxychloroquine Sulfate: 6 people, 8.57%
Prednisolone: 6 people, 8.57%

What are other side effects people have besides Limb discomfort? *

Joint Pain: 35 people, 50.00%
Pain In Extremity: 27 people, 38.57%
Pain: 26 people, 37.14%
Urinary Tract Infection: 23 people, 32.86%
Hypotension (abnormally low blood pressure): 23 people, 32.86%
Malaise (a feeling of general discomfort or uneasiness): 22 people, 31.43%
Rashes (redness): 20 people, 28.57%
Headache (pain in head): 19 people, 27.14%
Drug Ineffective: 18 people, 25.71%
Weight Decreased: 18 people, 25.71%

What are the existing conditions these people have? *

Lupus Nephritis (a chronic inflammatory autoimmune disorder that may affect kidney tissue): 3 people, 4.29%
Renal Impairment (severely reduced kidney function): 2 people, 2.86%
Pain: 2 people, 2.86%
Osteoporosis (bones weak and more likely to break): 2 people, 2.86%
High Blood Pressure: 2 people, 2.86%
Gastric Disorder (disease of stomach): 2 people, 2.86%
Depression: 2 people, 2.86%
Postoperative Wound Infection: 1 person, 1.43%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 1 person, 1.43%
Migraine (headache): 1 person, 1.43%

* Approximation only. Some reports may have incomplete information.

Do you take Benlysta and have Limb discomfort?

- Check whether Limb discomfort is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Benlysta:

Benlysta (23,528 reports)

Limb discomfort treatments and more:

Limb discomfort (37,896 reports)

Browse all side effects of Benlysta:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Limb discomfort:

Limb discomfort (1,293 drugs)

Browse all the conditions that are associated with Limb discomfort:

Limb discomfort (1,076 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on belimumab (the active ingredients of Benlysta) and Benlysta (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.