Benzonatate and Adrenal insufficiency - a phase IV clinical study of FDA data

Summary:

Adrenal insufficiency is reported as a side effect among people who take Benzonatate (benzonatate), especially for people who are female, 60+ old, have been taking the drug for 6 - 12 months also take Spiriva, and have Renal cell carcinoma.

The phase IV clinical study analyzes which people have Adrenal insufficiency when taking Benzonatate. It is created by eHealthMe based on reports of 16,665 people who have side effects when taking Benzonatate from the FDA, and is updated regularly.

What is Benzonatate?

Benzonatate has active ingredients of benzonatate. It is often used in cough. eHealthMe is studying from 17,274 Benzonatate users. Check the latest studies of Benzonatate.

What is Adrenal insufficiency?

Adrenal insufficiency (a condition in which the adrenal glands do not produce adequate amounts of steroids) is found to be associated with 967 drugs and 1,092 conditions by eHealthMe. Check the latest studies of Adrenal insufficiency.

On Jul, 11, 2026

16,665 people reported to have side effects when taking Benzonatate.
Among them, 27 people (0.16%) have Adrenal insufficiency.

Could Benzonatate cause Adrenal insufficiency?

Among these 27 people:

How long have people been on Benzonatate when they have Adrenal insufficiency? *

What is the gender of people who have Adrenal insufficiency when taking Benzonatate? *

female: 74.07 %
male: 25.93 %

What is the age of people who have Adrenal insufficiency when taking Benzonatate? *

What are other drugs people take besides Benzonatate? *

What are other side effects people have besides Adrenal insufficiency? *

Deep Venous Thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis): 19 people, 70.37%
Weight Decreased: 17 people, 62.96%
Intervertebral Disc Protrusion (spinal disc protrusion): 17 people, 62.96%
Multiple Myeloma (cancer of the plasma cells): 17 people, 62.96%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 17 people, 62.96%
Back Pain: 16 people, 59.26%
Nausea (feeling of having an urge to vomit): 15 people, 55.56%
Dehydration (dryness resulting from the removal of water): 15 people, 55.56%
Urinary Tract Infection: 14 people, 51.85%
Emphysema (chronic respiratory disease - over inflation of the air sacs (alveoli) in the lungs): 14 people, 51.85%

What are the existing conditions these people have? *

Renal Cell Carcinoma (a kidney cancer): 6 people, 22.22%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 5 people, 18.52%
Oedema Peripheral (superficial swelling): 5 people, 18.52%
Insomnia (sleeplessness): 5 people, 18.52%
Allergic Rhinitis: 4 people, 14.81%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 4 people, 14.81%
Cardiac Failure Congestive: 4 people, 14.81%
Nosebleed (bleeding from nose): 4 people, 14.81%
Cardiomyopathy (weakening of the heart muscle): 4 people, 14.81%
Nausea (feeling of having an urge to vomit): 4 people, 14.81%

* Approximation only. Some reports may have incomplete information.

Do you take Benzonatate and have Adrenal insufficiency?

- Check whether Adrenal insufficiency is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Benzonatate:

Benzonatate (17,274 reports)

Browse all side effects of Benzonatate:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Adrenal insufficiency:

Adrenal insufficiency (967 drugs)

Browse all the conditions that are associated with Adrenal insufficiency:

Adrenal insufficiency (1,092 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on benzonatate (the active ingredients of Benzonatate) and Benzonatate (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.