Biotin and Hyperkeratosis - a phase IV clinical study of FDA data

Summary:

Hyperkeratosis is reported as a side effect among people who take Biotin (biotin), especially for people who are female, 60+ old, also take Fosamax, and have Osteoporosis.

The phase IV clinical study analyzes which people have Hyperkeratosis when taking Biotin. It is created by eHealthMe based on reports of 33,728 people who have side effects when taking Biotin from the FDA, and is updated regularly.

What is Biotin?

Biotin has active ingredients of biotin. It is often used in hair loss. eHealthMe is studying from 35,393 Biotin users. Check the latest studies of Biotin.

What is Hyperkeratosis?

Hyperkeratosis (thickening of the outer layer of the skin) is found to be associated with 775 drugs and 774 conditions by eHealthMe. Check the latest studies of Hyperkeratosis.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 31, 2026

33,728 people reported to have side effects when taking Biotin.
Among them, 50 people (0.15%) have Hyperkeratosis.

Among these 50 people:

What is the gender of people who have Hyperkeratosis when taking Biotin? *

female: 90 %
male: 10 %

What is the age of people who have Hyperkeratosis when taking Biotin? *

What are other drugs people take besides Biotin? *

What are other side effects people have besides Hyperkeratosis? *

Pain: 27 people, 54.00%
High Blood Pressure: 26 people, 52.00%
Nasopharyngitis (inflammation of the nasopharynx): 24 people, 48.00%
Asthma: 21 people, 42.00%
Fall: 20 people, 40.00%
Dry Skin: 20 people, 40.00%
Gait Disturbance: 20 people, 40.00%
Gastrointestinal Disorder (functional problems of gastrointestinal tract): 19 people, 38.00%
Panic Disorder: 18 people, 36.00%
Stress And Anxiety: 18 people, 36.00%

What are the existing conditions these people have? *

Osteoporosis (bones weak and more likely to break): 18 people, 36.00%
Osteopenia (a condition where bone mineral density is lower than normal): 16 people, 32.00%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 8 people, 16.00%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 6 people, 12.00%
Renal Cell Carcinoma (a kidney cancer): 5 people, 10.00%
High Blood Cholesterol: 4 people, 8.00%
Pain: 4 people, 8.00%
Hyperlipidaemia (presence of excess lipids in the blood): 3 people, 6.00%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 3 people, 6.00%
High Blood Pressure: 3 people, 6.00%

* Approximation only. Some reports may have incomplete information.

Do you take Biotin and have Hyperkeratosis?

- Check whether Hyperkeratosis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Biotin:

Biotin (35,393 reports)

Hyperkeratosis treatments and more:

Hyperkeratosis (8,056 reports)

Browse all side effects of Biotin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hyperkeratosis:

Hyperkeratosis (775 drugs)

Browse all the conditions that are associated with Hyperkeratosis:

Hyperkeratosis (774 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on biotin (the active ingredients of Biotin) and Biotin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.