Black cohosh and Joint swelling - a phase IV clinical study of FDA data

Summary:

Joint swelling is reported as a side effect among people who take Black cohosh (black cohosh), especially for people who are female, 40-49 old, also take Ibuprofen, and have High blood pressure.

The phase IV clinical study analyzes which people have Joint swelling when taking Black cohosh. It is created by eHealthMe based on reports of 1,221 people who have side effects when taking Black cohosh from the FDA, and is updated regularly.

What is Black cohosh?

Black cohosh has active ingredients of black cohosh. It is often used in menopause. eHealthMe is studying from 1,382 Black cohosh users. Check the latest studies of Black cohosh.

What is Joint swelling?

Joint swelling is found to be associated with 2,120 drugs and 2,940 conditions by eHealthMe. Check the latest studies of Joint swelling.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

1,221 people reported to have side effects when taking Black cohosh.
Among them, 32 people (2.62%) have Joint swelling.

Could Black cohosh cause Joint swelling?

Among these 32 people:

What is the gender of people who have Joint swelling when taking Black cohosh? *

female: 94.12 %
male: 5.88 %

What is the age of people who have Joint swelling when taking Black cohosh? *

What are other drugs people take besides Black cohosh? *

What are other side effects people have besides Joint swelling? *

Joint Pain: 26 people, 81.25%
Weight Increased: 21 people, 65.62%
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect): 21 people, 65.62%
Diabetes: 21 people, 65.62%
Pain: 21 people, 65.62%
Arthropathy: 20 people, 62.50%
Back Pain: 20 people, 62.50%
Nasal Congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels): 20 people, 62.50%
Acute Kidney Failure: 20 people, 62.50%
Mouth Ulcers: 20 people, 62.50%

What are the existing conditions these people have? *

High Blood Pressure: 22 people, 68.75%
Diabetes: 20 people, 62.50%
Depression: 20 people, 62.50%
Bone Pain: 20 people, 62.50%
Breast Cancer: 20 people, 62.50%
Metastases To Bone (cancer spreads to bone): 20 people, 62.50%
Pain: 3 people, 9.38%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 3 people, 9.38%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 2 people, 6.25%
Conjunctivitis (pink eye): 1 person, 3.12%

* Approximation only. Some reports may have incomplete information.

Do you take Black cohosh and have Joint swelling?

- Check whether Joint swelling is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Black cohosh:

Black cohosh (1,382 reports)

Joint swelling treatments and more:

Joint swelling (143,797 reports)

Browse all side effects of Black cohosh:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Joint swelling:

Joint swelling (2,120 drugs)

Browse all the conditions that are associated with Joint swelling:

Joint swelling (2,940 conditions)

Related publications that referenced our studies

Puvanendran R, Teo HZ, "Case report of use of Black Cohosh for carbamazepine induced hot flushes in a post menopausal woman", Maturitas, 2017 Jun .
Puvanendran R, Teo HZ, "Case report of use of Black Cohosh for carbamazepine induced hot flushes in a post menopausal woman", Maturitas, 2017 Jun .

How the study uses the data?

The study uses data from the FDA. It is based on black cohosh (the active ingredients of Black cohosh) and Black cohosh (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.