Botox and Appendicitis - a phase IV clinical study of FDA data

Summary:

Appendicitis is reported as a side effect among people who take Botox (botulinum toxin type a), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Promethazine, and have Multiple sclerosis.

The phase IV clinical study analyzes which people have Appendicitis when taking Botox. It is created by eHealthMe based on reports of 69,984 people who have side effects when taking Botox from the FDA, and is updated regularly.

What is Botox?

Botox has active ingredients of botulinum toxin type a. It is often used in migraine. eHealthMe is studying from 70,512 Botox users. Check the latest studies of Botox.

What is Appendicitis?

Appendicitis (inflammation of the appendix) is found to be associated with 844 drugs and 891 conditions by eHealthMe. Check the latest studies of Appendicitis.

On Feb, 02, 2026

69,984 people reported to have side effects when taking Botox.
Among them, 17 people (0.02%) have Appendicitis.

Among these 17 people:

How long have people been on Botox when they have Appendicitis? *

What is the gender of people who have Appendicitis when taking Botox? *

female: 81.25 %
male: 18.75 %

What is the age of people who have Appendicitis when taking Botox? *

What are other drugs people take besides Botox? *

What are other side effects people have besides Appendicitis? *

Dizziness: 3 people, 17.65%
Joint Pain: 2 people, 11.76%
Abdominal Pain: 2 people, 11.76%
Urinary Tract Infection: 2 people, 11.76%
Back Pain: 2 people, 11.76%
Malaise (a feeling of general discomfort or uneasiness): 2 people, 11.76%
Nausea (feeling of having an urge to vomit): 2 people, 11.76%
Headache (pain in head): 2 people, 11.76%
Fever: 1 person, 5.88%
Gait Disturbance: 1 person, 5.88%

What are the existing conditions these people have? *

Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 3 people, 17.65%
Urinary Tract Infection: 2 people, 11.76%
Skin Wrinkling (wrinkle on skin): 2 people, 11.76%
Muscle Spasms (muscle contraction): 2 people, 11.76%
Stress And Anxiety: 1 person, 5.88%
Nausea (feeling of having an urge to vomit): 1 person, 5.88%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 1 person, 5.88%
Muscle Spasticity (tight or stiff muscles and an inability to control those muscles): 1 person, 5.88%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 1 person, 5.88%
Hyperlipidaemia (presence of excess lipids in the blood): 1 person, 5.88%

* Approximation only. Some reports may have incomplete information.

Do you take Botox and have Appendicitis?

- Check whether Appendicitis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Botox:

Botox (70,512 reports)

Appendicitis treatments and more:

Appendicitis (11,953 reports)

Browse all side effects of Botox:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Appendicitis:

Appendicitis (844 drugs)

Browse all the conditions that are associated with Appendicitis:

Appendicitis (891 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on botulinum toxin type a (the active ingredients of Botox) and Botox (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.