Botox and Hypotonia - a phase IV clinical study of FDA data

Summary:

Hypotonia is reported as a side effect among people who take Botox (botulinum toxin type a), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Lioresal, and have Muscle spasticity.

The phase IV clinical study analyzes which people have Hypotonia when taking Botox. It is created by eHealthMe based on reports of 69,984 people who have side effects when taking Botox from the FDA, and is updated regularly.

What is Botox?

Botox has active ingredients of botulinum toxin type a. It is often used in migraine. eHealthMe is studying from 70,513 Botox users. Check the latest studies of Botox.

What is Hypotonia?

Hypotonia (low muscle tone) is found to be associated with 834 drugs and 1,766 conditions by eHealthMe. Check the latest studies of Hypotonia.

On Apr, 15, 2026

69,984 people reported to have side effects when taking Botox.
Among them, 80 people (0.11%) have Hypotonia.

Among these 80 people:

How long have people been on Botox when they have Hypotonia? *

What is the gender of people who have Hypotonia when taking Botox? *

female: 57.89 %
male: 42.11 %

What is the age of people who have Hypotonia when taking Botox? *

What are other drugs people take besides Botox? *

What are other side effects people have besides Hypotonia? *

Weakness: 22 people, 27.50%
Overdose: 9 people, 11.25%
Fatigue (feeling of tiredness): 9 people, 11.25%
Botulism (food poisoning caused by botulinum growing): 9 people, 11.25%
Swallowing Difficulty: 9 people, 11.25%
Gait Disturbance: 7 people, 8.75%
Muscle Spasticity (tight or stiff muscles and an inability to control those muscles): 6 people, 7.50%
Headache (pain in head): 6 people, 7.50%
Pain: 6 people, 7.50%
Feeling Abnormal: 6 people, 7.50%

What are the existing conditions these people have? *

Muscle Spasticity (tight or stiff muscles and an inability to control those muscles): 28 people, 35.00%
Skin Wrinkling (wrinkle on skin): 9 people, 11.25%
Cerebral Palsy: 5 people, 6.25%
Muscle Contracture (a permanent shortening of a muscle): 3 people, 3.75%
Muscle Spasms (muscle contraction): 3 people, 3.75%
Torticollis (a twisted neck in which the head is tipped to one side, while the chin is turned to the other): 3 people, 3.75%
Pain: 2 people, 2.50%
Bruxism (habitual grinding of the teeth, typically during sleep): 2 people, 2.50%
Sedation: 2 people, 2.50%
Facial Spasm (involuntary muscle contractions face): 2 people, 2.50%

* Approximation only. Some reports may have incomplete information.

Do you take Botox and have Hypotonia?

- Check whether Hypotonia is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Botox:

Botox (70,513 reports)

Hypotonia treatments and more:

Hypotonia (14,614 reports)

Browse all side effects of Botox:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hypotonia:

Hypotonia (834 drugs)

Browse all the conditions that are associated with Hypotonia:

Hypotonia (1,766 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on botulinum toxin type a (the active ingredients of Botox) and Botox (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.