Botox and Toothaches - a phase IV clinical study of FDA data

Summary:

Toothaches is reported as a side effect among people who take Botox (botulinum toxin type a), especially for people who are female, 40-49 old, have been taking the drug for < 1 month also take Zometa, and have Skin wrinkling.

The phase IV clinical study analyzes which people have Toothaches when taking Botox. It is created by eHealthMe based on reports of 69,984 people who have side effects when taking Botox from the FDA, and is updated regularly.

What is Botox?

Botox has active ingredients of botulinum toxin type a. It is often used in migraine. eHealthMe is studying from 70,513 Botox users. Check the latest studies of Botox.

What is Toothaches?

Toothaches (tooth pain) is found to be associated with 1,320 drugs and 1,606 conditions by eHealthMe. Check the latest studies of Toothaches.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 18, 2026

69,984 people reported to have side effects when taking Botox.
Among them, 77 people (0.11%) have Toothaches.

Among these 77 people:

How long have people been on Botox when they have Toothaches? *

What is the gender of people who have Toothaches when taking Botox? *

female: 94.67 %
male: 5.33 %

What is the age of people who have Toothaches when taking Botox? *

What are other drugs people take besides Botox? *

What are other side effects people have besides Toothaches? *

Stress And Anxiety: 25 people, 32.47%
Depression: 24 people, 31.17%
Pain: 24 people, 31.17%
Rashes (redness): 23 people, 29.87%
Tooth Disorder (tooth disease): 23 people, 29.87%
Swelling Face: 21 people, 27.27%
Hypoaesthesia Oral (reduced sense of touch or sensation in mouth): 21 people, 27.27%
Swelling: 21 people, 27.27%
Hypoaesthesia (reduced sense of touch or sensation): 21 people, 27.27%
Dental Caries: 20 people, 25.97%

What are the existing conditions these people have? *

Skin Wrinkling (wrinkle on skin): 20 people, 25.97%
Neoplasm Malignant (cancer tumour): 18 people, 23.38%
Pain: 15 people, 19.48%
Depression: 14 people, 18.18%
Pain In Jaw: 12 people, 15.58%
Headache (pain in head): 7 people, 9.09%
Stress And Anxiety: 7 people, 9.09%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 4 people, 5.19%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 3 people, 3.90%
Fibromyalgia (a long-term condition which causes pain all over the body): 3 people, 3.90%

* Approximation only. Some reports may have incomplete information.

Do you take Botox and have Toothaches?

- Check whether Toothaches is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Botox:

Botox (70,513 reports)

Toothaches treatments and more:

Toothaches (28,231 reports)

Browse all side effects of Botox:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Toothaches:

Toothaches (1,320 drugs)

Browse all the conditions that are associated with Toothaches:

Toothaches (1,606 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on botulinum toxin type a (the active ingredients of Botox) and Botox (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.