Buphenyl and Ammonia increased - a phase IV clinical study of FDA data

Summary:

Ammonia increased is reported as a side effect among people who take Buphenyl (sodium phenylbutyrate), especially for people who are female, 10-19 old, have been taking the drug for < 1 month also take Ravicti, and have Acidosis.

The phase IV clinical study analyzes which people have Ammonia increased when taking Buphenyl. It is created by eHealthMe based on reports of 287 people who have side effects when taking Buphenyl from the FDA, and is updated regularly.

What is Buphenyl?

Buphenyl has active ingredients of sodium phenylbutyrate. eHealthMe is studying from 287 Buphenyl users. Check the latest studies of Buphenyl.

What is Ammonia increased?

Ammonia increased is found to be associated with 554 drugs and 764 conditions by eHealthMe. Check the latest studies of Ammonia increased.

On Jul, 15, 2026

287 people reported to have side effects when taking Buphenyl.
Among them, 22 people (7.67%) have Ammonia increased.

Among these 22 people:

How long have people been on Buphenyl when they have Ammonia increased? *

What is the gender of people who have Ammonia increased when taking Buphenyl? *

female: 70.59 %
male: 29.41 %

What is the age of people who have Ammonia increased when taking Buphenyl? *

What are other drugs people take besides Buphenyl? *

What are other side effects people have besides Ammonia increased? *

Fatigue (feeling of tiredness): 5 people, 22.73%
Abdominal Pain Upper: 3 people, 13.64%
Nausea And Vomiting: 2 people, 9.09%
Hepatic Enzyme Increased: 2 people, 9.09%
Drug Intolerance (drug sensitivity): 2 people, 9.09%
Head Injury: 2 people, 9.09%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 2 people, 9.09%
International Normalised Ratio Increased: 2 people, 9.09%
Hepatic Failure (liver failure): 1 person, 4.55%
Dementia Due To Pick's Disease (madness due to pick's disease): 1 person, 4.55%

What are the existing conditions these people have? *

Hyperammonaemia: 1 person, 4.55%
Cytogenetic Abnormality: 1 person, 4.55%
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 1 person, 4.55%
Carnitine Deficiency: 1 person, 4.55%
Argininosuccinate Synthetase Deficiency: 1 person, 4.55%
Arginase Deficiency (inherited disorder that causes the amino acid arginine (a building block of proteins) and ammonia to accumulate gradually in the blood): 1 person, 4.55%
Amino Acid Metabolism Disorder: 1 person, 4.55%
Acidosis (build-up of carbon dioxide in the blood): 1 person, 4.55%

* Approximation only. Some reports may have incomplete information.

Do you take Buphenyl and have Ammonia increased?

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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Buphenyl:

Buphenyl (287 reports)

Browse all side effects of Buphenyl:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Ammonia increased:

Ammonia increased (554 drugs)

Browse all the conditions that are associated with Ammonia increased:

Ammonia increased (764 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on sodium phenylbutyrate (the active ingredients of Buphenyl) and Buphenyl (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.