Bupropion hydrobromide and Middle insomnia - a phase IV clinical study of FDA data

Summary:

Middle insomnia is reported as a side effect among people who take Bupropion hydrobromide (bupropion hydrobromide), especially for people who are female, 50-59 old, also take Abilify, and have Migraine.

The phase IV clinical study analyzes which people have Middle insomnia when taking Bupropion hydrobromide. It is created by eHealthMe based on reports of 371 people who have side effects when taking Bupropion hydrobromide from the FDA, and is updated regularly.

What is Bupropion hydrobromide?

Bupropion hydrobromide has active ingredients of bupropion hydrobromide. It is often used in depression. eHealthMe is studying from 659 Bupropion hydrobromide users. Check the latest studies of Bupropion hydrobromide.

What is Middle insomnia?

Middle insomnia (difficulty returning to sleep after awakening either in the middle of the night) is found to be associated with 990 drugs and 970 conditions by eHealthMe. Check the latest studies of Middle insomnia.

On Jul, 04, 2026

371 people reported to have side effects when taking Bupropion hydrobromide.
Among them, 31 people (8.36%) have Middle insomnia.

Could Bupropion hydrobromide cause Middle insomnia?

Among these 31 people:

What is the gender of people who have Middle insomnia when taking Bupropion hydrobromide? *

female: 100 %
male: 0.0 %

What is the age of people who have Middle insomnia when taking Bupropion hydrobromide? *

What are other drugs people take besides Bupropion hydrobromide? *

Zopiclone: 31 people, 100.00%
Lyrica: 31 people, 100.00%
Abilify: 31 people, 100.00%
Fluoxetine: 29 people, 93.55%
Cymbalta: 29 people, 93.55%
Wellbutrin: 29 people, 93.55%
Tylenol: 28 people, 90.32%
Vortioxetine Hydrobromide: 28 people, 90.32%
Codeine: 27 people, 87.10%
Norflex: 27 people, 87.10%

What are other side effects people have besides Middle insomnia? *

Memory Loss: 31 people, 100.00%
Migraine (headache): 31 people, 100.00%
Concussion (short loss of normal brain function in response to a head injury): 31 people, 100.00%
Diarrhea: 31 people, 100.00%
Dizziness: 31 people, 100.00%
Drowsiness: 31 people, 100.00%
Feeling Hot: 31 people, 100.00%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 31 people, 100.00%
Headache (pain in head): 31 people, 100.00%
Hostility: 31 people, 100.00%

What are the existing conditions these people have? *

Migraine (headache): 30 people, 96.77%
Pain: 18 people, 58.06%

* Approximation only. Some reports may have incomplete information.

Do you take Bupropion hydrobromide and have Middle insomnia?

- Check whether Middle insomnia is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Bupropion hydrobromide:

Bupropion hydrobromide (659 reports)

Middle insomnia treatments and more:

Middle insomnia (21,951 reports)

Browse all side effects of Bupropion hydrobromide:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Middle insomnia:

Middle insomnia (990 drugs)

Browse all the conditions that are associated with Middle insomnia:

Middle insomnia (970 conditions)

Related publications that referenced our studies

Kate N, Grover S, Kumar S, Modi M, "Bupropion-induced hyponatremia", General hospital psychiatry, 2013 Dec .
Kate N, Grover S, Kumar S, Modi M, "Bupropion-induced hyponatremia", General hospital psychiatry, 2013 Dec .

How the study uses the data?

The study uses data from the FDA. It is based on bupropion hydrobromide (the active ingredients of Bupropion hydrobromide) and Bupropion hydrobromide (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.