Buspar and Dysphoria - a phase IV clinical study of FDA data

Summary:

Dysphoria is reported as a side effect among people who take Buspar (buspirone hydrochloride), especially for people who are female, 20-29 old, also take Neurontin, and have Pain.

The phase IV clinical study analyzes which people have Dysphoria when taking Buspar. It is created by eHealthMe based on reports of 17,598 people who have side effects when taking Buspar from the FDA, and is updated regularly.

What is Buspar?

Buspar has active ingredients of buspirone hydrochloride. It is often used in stress and anxiety. eHealthMe is studying from 20,464 Buspar users. Check the latest studies of Buspar.

What is Dysphoria?

Dysphoria (generalized dissatisfaction with life) is found to be associated with 348 drugs and 538 conditions by eHealthMe. Check the latest studies of Dysphoria.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 31, 2026

17,598 people reported to have side effects when taking Buspar.
Among them, 46 people (0.26%) have Dysphoria.

Among these 46 people:

What is the gender of people who have Dysphoria when taking Buspar? *

female: 73.33 %
male: 26.67 %

What is the age of people who have Dysphoria when taking Buspar? *

What are other drugs people take besides Buspar? *

What are other side effects people have besides Dysphoria? *

Suicidal Ideation: 33 people, 71.74%
Weakness: 30 people, 65.22%
Confusional State: 30 people, 65.22%
Chest Pain: 26 people, 56.52%
Drug Withdrawal Syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation): 24 people, 52.17%
Paranoia (psychotic disorder characterized by delusions of persecution with or without grandeur): 24 people, 52.17%
Drug Dependence: 23 people, 50.00%
Headache (pain in head): 23 people, 50.00%
Back Pain: 22 people, 47.83%
Post-Traumatic Stress Disorder: 21 people, 45.65%

What are the existing conditions these people have? *

Pain: 18 people, 39.13%
Bipolar Disorder (mood disorder): 14 people, 30.43%
Sleep Disorder: 12 people, 26.09%
Headache (pain in head): 12 people, 26.09%
Drug Dependence: 3 people, 6.52%
Alcoholism (problems with alcohol): 3 people, 6.52%
Neuropathy Peripheral (surface nerve damage): 1 person, 2.17%
Nerve Injury: 1 person, 2.17%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 1 person, 2.17%
Major Depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings): 1 person, 2.17%

* Approximation only. Some reports may have incomplete information.

Do you take Buspar and have Dysphoria?

- Check whether Dysphoria is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Buspar:

Buspar (20,464 reports)

Dysphoria treatments and more:

Dysphoria (5,565 reports)

Browse all side effects of Buspar:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Dysphoria:

Dysphoria (348 drugs)

Browse all the conditions that are associated with Dysphoria:

Dysphoria (538 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on buspirone hydrochloride (the active ingredients of Buspar) and Buspar (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.