Buspirone hcl and Knee joint replacement - a phase IV clinical study of FDA data

Summary:

Knee joint replacement is reported as a side effect among people who take Buspirone hcl (buspirone hydrochloride), especially for people who are female, 60+ old, also take Xyrem, and have Narcolepsy.

The phase IV clinical study analyzes which people have Knee joint replacement when taking Buspirone hcl. It is created by eHealthMe based on reports of 8,801 people who have side effects when taking Buspirone hcl from the FDA, and is updated regularly.

What is Buspirone hcl?

Buspirone hcl has active ingredients of buspirone hydrochloride. It is often used in stress and anxiety. eHealthMe is studying from 9,821 Buspirone hcl users. Check the latest studies of Buspirone hcl.

What is Knee joint replacement?

Knee joint replacement is found to be associated with 948 drugs and 1,232 conditions by eHealthMe. Check the latest studies of Knee joint replacement.

On Aug, 02, 2026

8,801 people reported to have side effects when taking Buspirone hcl.
Among them, 34 people (0.39%) have Knee joint replacement.

Could Buspirone hcl cause Knee joint replacement?

Among these 34 people:

What is the gender of people who have Knee joint replacement when taking Buspirone hcl? *

female: 63.64 %
male: 36.36 %

What is the age of people who have Knee joint replacement when taking Buspirone hcl? *

What are other drugs people take besides Buspirone hcl? *

What are other side effects people have besides Knee joint replacement? *

Back Pain: 11 people, 32.35%
Headache (pain in head): 6 people, 17.65%
Peripheral Swelling: 4 people, 11.76%
Rickets (softening of bones): 4 people, 11.76%
Fall: 4 people, 11.76%
Joint Swelling: 4 people, 11.76%
Weight Decreased: 4 people, 11.76%
Diarrhea: 4 people, 11.76%
Cystitis Interstitial (unknown cause characterized by bladder pain): 4 people, 11.76%
Cough: 4 people, 11.76%

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 18 people, 52.94%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 10 people, 29.41%
Drowsiness: 9 people, 26.47%
Immunodeficiency Common Variable: 4 people, 11.76%
Nausea (feeling of having an urge to vomit): 4 people, 11.76%
Idiopathic Pulmonary Fibrosis (chronic lung disease): 2 people, 5.88%
Gilles De La Tourette Syndrome (a condition that causes people to make repeated, quick movements or sounds that they cannot control): 2 people, 5.88%
High Blood Cholesterol: 2 people, 5.88%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 2 people, 5.88%
Short-Bowel Syndrome (a condition in which the body cannot absorb enough fluids and nutrients because part of the small intestine is missing): 2 people, 5.88%

* Approximation only. Some reports may have incomplete information.

Do you take Buspirone hcl and have Knee joint replacement?

- Check whether Knee joint replacement is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Buspirone hcl:

Buspirone hcl (9,821 reports)

Browse all side effects of Buspirone hcl:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Knee joint replacement:

Knee joint replacement (948 drugs)

Browse all the conditions that are associated with Knee joint replacement:

Knee joint replacement (1,232 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on buspirone hydrochloride (the active ingredients of Buspirone hcl) and Buspirone hcl (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.