Buspirone hcl and Middle insomnia - a phase IV clinical study of FDA data

Summary:

Middle insomnia is reported as a side effect among people who take Buspirone hcl (buspirone hydrochloride), especially for people who are female, 60+ old, have been taking the drug for 1 - 6 months also take Hetlioz, and have Asthma.

The phase IV clinical study analyzes which people have Middle insomnia when taking Buspirone hcl. It is created by eHealthMe based on reports of 8,801 people who have side effects when taking Buspirone hcl from the FDA, and is updated regularly.

What is Buspirone hcl?

Buspirone hcl has active ingredients of buspirone hydrochloride. It is often used in stress and anxiety. eHealthMe is studying from 9,821 Buspirone hcl users. Check the latest studies of Buspirone hcl.

What is Middle insomnia?

Middle insomnia (difficulty returning to sleep after awakening either in the middle of the night) is found to be associated with 985 drugs and 972 conditions by eHealthMe. Check the latest studies of Middle insomnia.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 29, 2026

8,801 people reported to have side effects when taking Buspirone hcl.
Among them, 27 people (0.31%) have Middle insomnia.

Could Buspirone hcl cause Middle insomnia?

Among these 27 people:

How long have people been on Buspirone hcl when they have Middle insomnia? *

What is the gender of people who have Middle insomnia when taking Buspirone hcl? *

female: 68 %
male: 32 %

What is the age of people who have Middle insomnia when taking Buspirone hcl? *

What are other drugs people take besides Buspirone hcl? *

What are other side effects people have besides Middle insomnia? *

Drug Ineffective: 7 people, 25.93%
Chest Pain: 6 people, 22.22%
Joint Pain: 5 people, 18.52%
Initial Insomnia (feeling of inadequate or poor-quality sleep): 5 people, 18.52%
Gait Disturbance: 4 people, 14.81%
Pain: 4 people, 14.81%
Headache (pain in head): 4 people, 14.81%
Poor Quality Sleep: 4 people, 14.81%
Hyperhidrosis (abnormally increased sweating): 3 people, 11.11%
Nausea (feeling of having an urge to vomit): 3 people, 11.11%

What are the existing conditions these people have? *

Asthma: 4 people, 14.81%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 3 people, 11.11%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 3 people, 11.11%
Wheezing (a high-pitched whistling sound made while you breath): 1 person, 3.70%
Ulcerative Colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine): 1 person, 3.70%
Restless Leg Syndrome (a powerful urge to move your legs): 1 person, 3.70%
Pain: 1 person, 3.70%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 1 person, 3.70%
Movement - Uncontrolled Or Slow: 1 person, 3.70%
Insomnia (sleeplessness): 1 person, 3.70%

* Approximation only. Some reports may have incomplete information.

Do you take Buspirone hcl and have Middle insomnia?

- Check whether Middle insomnia is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Buspirone hcl:

Buspirone hcl (9,821 reports)

Middle insomnia treatments and more:

Middle insomnia (21,952 reports)

Browse all side effects of Buspirone hcl:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Middle insomnia:

Middle insomnia (985 drugs)

Browse all the conditions that are associated with Middle insomnia:

Middle insomnia (972 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on buspirone hydrochloride (the active ingredients of Buspirone hcl) and Buspirone hcl (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.