Butrans and Sciatica - a phase IV clinical study of FDA data

Summary:

Sciatica is reported as a side effect among people who take Butrans (buprenorphine), especially for people who are female, 60+ old, have been taking the drug for 1 - 6 months also take Diclofenac, and have Muscle spasms.

The phase IV clinical study analyzes which people have Sciatica when taking Butrans. It is created by eHealthMe based on reports of 63,939 people who have side effects when taking Butrans from the FDA, and is updated regularly.

What is Butrans?

Butrans has active ingredients of buprenorphine. It is often used in pain. eHealthMe is studying from 64,148 Butrans users. Check the latest studies of Butrans.

What is Sciatica?

Sciatica (a set of symptoms including pain caused by general compression or irritation of one of five spinal nerve roots of each sciatic nerve) is found to be associated with 1,144 drugs and 1,429 conditions by eHealthMe. Check the latest studies of Sciatica.

On Apr, 18, 2026

63,939 people reported to have side effects when taking Butrans.
Among them, 30 people (0.05%) have Sciatica.

Among these 30 people:

How long have people been on Butrans when they have Sciatica? *

What is the gender of people who have Sciatica when taking Butrans? *

female: 85.71 %
male: 14.29 %

What is the age of people who have Sciatica when taking Butrans? *

What are other drugs people take besides Butrans? *

Diclofenac: 16 people, 53.33%
Acetaminophen: 10 people, 33.33%
Lyrica: 10 people, 33.33%
Celebrex: 9 people, 30.00%
Prednisone: 9 people, 30.00%
Calcium Carbonate: 9 people, 30.00%
Naproxen Sodium: 9 people, 30.00%
Atomoxetine Hydrochloride: 9 people, 30.00%
Simponi: 9 people, 30.00%
Diclofenac Sodium: 9 people, 30.00%

What are other side effects people have besides Sciatica? *

Dyspnea (difficult or laboured breathing): 18 people, 60.00%
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect): 17 people, 56.67%
Confusional State: 17 people, 56.67%
Nausea And Vomiting: 13 people, 43.33%
Pneumonia: 13 people, 43.33%
Chest Pain: 13 people, 43.33%
Nausea (feeling of having an urge to vomit): 12 people, 40.00%
Oedema Peripheral (superficial swelling): 12 people, 40.00%
Pain In Extremity: 12 people, 40.00%
Joint Pain: 12 people, 40.00%

What are the existing conditions these people have? *

Stress And Anxiety: 10 people, 33.33%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 10 people, 33.33%
Muscle Spasms (muscle contraction): 10 people, 33.33%
Oedema (fluid collection in tissue): 9 people, 30.00%
Gastric Ulcer (stomach ulcer): 9 people, 30.00%
Migraine (headache): 9 people, 30.00%
Agitation (state of anxiety or nervous excitement): 9 people, 30.00%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 8 people, 26.67%
Back Pain: 8 people, 26.67%
Reflux Gastritis (a condition in which the lining of a person's stomach becomes inflamed as a result of exposure to bile): 8 people, 26.67%

* Approximation only. Some reports may have incomplete information.

Do you take Butrans and have Sciatica?

- Check whether Sciatica is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Butrans:

Butrans (64,148 reports)

Sciatica treatments and more:

Sciatica (28,509 reports)

Browse all side effects of Butrans:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Sciatica:

Sciatica (1,144 drugs)

Browse all the conditions that are associated with Sciatica:

Sciatica (1,429 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on buprenorphine (the active ingredients of Butrans) and Butrans (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.