Caffeine citrate and Knee joint replacement - a phase IV clinical study of FDA data

Summary:

Knee joint replacement is reported as a side effect among people who take Caffeine citrate (caffeine citrate), especially for people who are female, 40-49 old, also take Humira, and have Rheumatoid arthritis.

The phase IV clinical study analyzes which people have Knee joint replacement when taking Caffeine citrate. It is created by eHealthMe based on reports of 2,319 people who have side effects when taking Caffeine citrate from the FDA, and is updated regularly.

What is Caffeine citrate?

Caffeine citrate has active ingredients of caffeine citrate. It is often used in fatigue. eHealthMe is studying from 2,424 Caffeine citrate users. Check the latest studies of Caffeine citrate.

What is Knee joint replacement?

Knee joint replacement is found to be associated with 953 drugs and 1,228 conditions by eHealthMe. Check the latest studies of Knee joint replacement.

On Jul, 08, 2026

2,319 people reported to have side effects when taking Caffeine citrate.
Among them, 404 people (17.42%) have Knee joint replacement.

Could Caffeine citrate cause Knee joint replacement?

Among these 404 people:

What is the gender of people who have Knee joint replacement when taking Caffeine citrate? *

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What is the age of people who have Knee joint replacement when taking Caffeine citrate? *

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* Approximation only. Some reports may have incomplete information.

Do you take Caffeine citrate and have Knee joint replacement?

- Check whether Knee joint replacement is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Caffeine citrate:

Caffeine citrate (2,424 reports)

Knee joint replacement treatments and more:

Knee joint replacement (26,755 reports)

How severe was Knee joint replacement and when was it recovered:

Knee joint replacement in Caffeine citrate

Expand to all the drugs that have ingredients of caffeine citrate:

Knee joint replacement and drugs with ingredients of caffeine citrate

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Caffeine citrate:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Knee joint replacement:

Knee joint replacement (953 drugs)

Browse all the conditions that are associated with Knee joint replacement:

Knee joint replacement (1,228 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on caffeine citrate (the active ingredients of Caffeine citrate) and Caffeine citrate (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.