Caffeine and Serotonin syndrome - a phase IV clinical study of FDA data

Summary:

Serotonin syndrome is reported as a side effect among people who take Caffeine (caffeine), especially for people who are female, 30-39 old, also take Sertraline, and have Depression.

The phase IV clinical study analyzes which people have Serotonin syndrome when taking Caffeine. It is created by eHealthMe based on reports of 6,333 people who have side effects when taking Caffeine from the FDA, and is updated regularly.

What is Caffeine?

Caffeine has active ingredients of caffeine. It is often used in fatigue. eHealthMe is studying from 6,667 Caffeine users. Check the latest studies of Caffeine.

What is Serotonin syndrome?

Serotonin syndrome (occurs when two drugs that affect the body's level of serotonin are taken together at the same time) is found to be associated with 716 drugs and 1,199 conditions by eHealthMe. Check the latest studies of Serotonin syndrome.

On Jul, 16, 2026

6,333 people reported to have side effects when taking Caffeine.
Among them, 46 people (0.73%) have Serotonin syndrome.

Could Caffeine cause Serotonin syndrome?

Among these 46 people:

What is the gender of people who have Serotonin syndrome when taking Caffeine? *

female: 65.85 %
male: 34.15 %

What is the age of people who have Serotonin syndrome when taking Caffeine? *

What are other drugs people take besides Caffeine? *

What are other side effects people have besides Serotonin syndrome? *

Overdose: 11 people, 23.91%
Pulmonary Oedema (fluid accumulation in the lungs): 9 people, 19.57%
Respiratory Depression (respiration has a rate below 12 breaths): 7 people, 15.22%
Atherosclerosis (disorder of the arteries): 7 people, 15.22%
Pneumonia: 7 people, 15.22%
Consciousness - Decreased: 6 people, 13.04%
Maternal Exposure During Pregnancy (use of substance during pregnancy): 6 people, 13.04%
Metabolic Acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body): 6 people, 13.04%
Toxic Encephalopathy (a degenerative neurologic disorder caused by exposure to toxic substances): 6 people, 13.04%
Electroencephalogram Abnormal: 6 people, 13.04%

What are the existing conditions these people have? *

Depression: 11 people, 23.91%
Mania (a state of abnormally elevated or irritable mood): 9 people, 19.57%
Nausea And Vomiting: 8 people, 17.39%
Nausea (feeling of having an urge to vomit): 8 people, 17.39%
Eating Disorder: 6 people, 13.04%
Suicide Attempt: 5 people, 10.87%
Generalized Anxiety Disorder (excessive, uncontrollable, unexplained and often irrational worry): 3 people, 6.52%
Bipolar I Disorder (mood disorder that is characterized by at least one manic or mixed episode): 3 people, 6.52%
Feeling Of Despair: 2 people, 4.35%
Ventricular Tachycardia (rapid heartbeat that originates in one of the lower chambers (the ventricles) of the heart): 1 person, 2.17%

* Approximation only. Some reports may have incomplete information.

Do you take Caffeine and have Serotonin syndrome?

- Check whether Serotonin syndrome is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Caffeine:

Caffeine (6,667 reports)

Browse all side effects of Caffeine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Serotonin syndrome:

Serotonin syndrome (716 drugs)

Browse all the conditions that are associated with Serotonin syndrome:

Serotonin syndrome (1,199 conditions)

Related publications that referenced our studies

Behnoush B, Memarian A, Teimoory M, "Naltrexone Induced Serotonin Syndrome", International Journal of Medical Toxicology and Forensic Medicine, 2013 Apr .
Behnoush B, Memarian A, Teimoory M, "Naltrexone Induced Serotonin Syndrome", International Journal of Medical Toxicology and Forensic Medicine, 2013 Apr .

How the study uses the data?

The study uses data from the FDA. It is based on caffeine (the active ingredients of Caffeine) and Caffeine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.