Calcium citrate and Middle insomnia - a phase IV clinical study of FDA data

Summary:

Middle insomnia is reported as a side effect among people who take Calcium citrate (calcium), especially for people who are female, 60+ old, also take Fish Oil, and have Burning sensation.

The phase IV clinical study analyzes which people have Middle insomnia when taking Calcium citrate. It is created by eHealthMe based on reports of 12,169 people who have side effects when taking Calcium citrate from the FDA, and is updated regularly.

What is Calcium citrate?

Calcium citrate has active ingredients of calcium. It is often used in osteopenia. eHealthMe is studying from 12,607 Calcium citrate users. Check the latest studies of Calcium citrate.

What is Middle insomnia?

Middle insomnia (difficulty returning to sleep after awakening either in the middle of the night) is found to be associated with 983 drugs and 972 conditions by eHealthMe. Check the latest studies of Middle insomnia.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 29, 2026

12,169 people reported to have side effects when taking Calcium citrate.
Among them, 25 people (0.21%) have Middle insomnia.

Could Calcium citrate cause Middle insomnia?

Among these 25 people:

What is the gender of people who have Middle insomnia when taking Calcium citrate? *

female: 78.26 %
male: 21.74 %

What is the age of people who have Middle insomnia when taking Calcium citrate? *

What are other drugs people take besides Calcium citrate? *

What are other side effects people have besides Middle insomnia? *

Stress And Anxiety: 8 people, 32.00%
Insomnia (sleeplessness): 6 people, 24.00%
Drowsiness: 4 people, 16.00%
Nightmares (unpleasant dreams): 4 people, 16.00%
Fatigue (feeling of tiredness): 4 people, 16.00%
Initial Insomnia (feeling of inadequate or poor-quality sleep): 3 people, 12.00%
Fall: 3 people, 12.00%
Swallowing Difficulty: 3 people, 12.00%
Constipation: 3 people, 12.00%
Abnormal Dreams: 3 people, 12.00%

What are the existing conditions these people have? *

Macular Degeneration (painless eye condition that leads to the gradual loss of central vision): 4 people, 16.00%
Burning Sensation: 4 people, 16.00%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 2 people, 8.00%
Neuropathy Peripheral (surface nerve damage): 2 people, 8.00%
Fibromyalgia (a long-term condition which causes pain all over the body): 2 people, 8.00%
Migraine (headache): 2 people, 8.00%
Depression: 2 people, 8.00%
Circadian Rhythm Sleep Disorder (family of sleep disorders affecting, among other things, the timing of sleep): 2 people, 8.00%
Cystic Fibrosis (disease of the secretary glands): 2 people, 8.00%
Sleep Disorder: 2 people, 8.00%

* Approximation only. Some reports may have incomplete information.

Do you take Calcium citrate and have Middle insomnia?

- Check whether Middle insomnia is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Calcium citrate:

Calcium citrate (12,607 reports)

Middle insomnia treatments and more:

Middle insomnia (21,952 reports)

Browse all side effects of Calcium citrate:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Middle insomnia:

Middle insomnia (983 drugs)

Browse all the conditions that are associated with Middle insomnia:

Middle insomnia (972 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on calcium (the active ingredients of Calcium citrate) and Calcium citrate (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.