Calcium citrate and Optic nerve cupping - a phase IV clinical study of FDA data

Summary:

Optic nerve cupping is reported as a side effect among people who take Calcium citrate (calcium), especially for people who are female, 60+ old, also take Omeprazole, and have Multiple myeloma.

The phase IV clinical study analyzes which people have Optic nerve cupping when taking Calcium citrate. It is created by eHealthMe based on reports of 12,169 people who have side effects when taking Calcium citrate from the FDA, and is updated regularly.

What is Calcium citrate?

Calcium citrate has active ingredients of calcium. It is often used in osteopenia. eHealthMe is studying from 12,607 Calcium citrate users. Check the latest studies of Calcium citrate.

What is Optic nerve cupping?

Optic nerve cupping (the size of the depression in the middle of the nerve when viewed from the front of the eye) is found to be associated with 80 drugs and 110 conditions by eHealthMe. Check the latest studies of Optic nerve cupping.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 23, 2026

12,169 people reported to have side effects when taking Calcium citrate.
Among them, 12 people (0.1%) have Optic nerve cupping.

Could Calcium citrate cause Optic nerve cupping?

Among these 12 people:

What is the gender of people who have Optic nerve cupping when taking Calcium citrate? *

female: 100 %
male: 0.0 %

What is the age of people who have Optic nerve cupping when taking Calcium citrate? *

What are other drugs people take besides Calcium citrate? *

What are other side effects people have besides Optic nerve cupping? *

Weakness: 12 people, 100.00%
Movement Disorder (neurological syndromes where they may be excess of movement or a paucity of movement that is not connected to weakness): 12 people, 100.00%
Pain In Extremity: 12 people, 100.00%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 12 people, 100.00%
Osteonecrosis Of Jaw (death of bone of jaw): 12 people, 100.00%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 12 people, 100.00%
Oedema Peripheral (superficial swelling): 12 people, 100.00%
Neuralgia (pain in one or more nerves): 12 people, 100.00%
Nerve Root Lesion (a localized change in nerve root tissue): 12 people, 100.00%
Neck Pain: 12 people, 100.00%

What are the existing conditions these people have? *

Multiple Myeloma (cancer of the plasma cells): 12 people, 100.00%
High Blood Pressure: 5 people, 41.67%
Febrile Neutropenia (fever with reduced white blood cells): 5 people, 41.67%
Breast Cancer Metastatic: 1 person, 8.33%

* Approximation only. Some reports may have incomplete information.

Do you take Calcium citrate and have Optic nerve cupping?

- Check whether Optic nerve cupping is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Calcium citrate:

Calcium citrate (12,607 reports)

Browse all side effects of Calcium citrate:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Optic nerve cupping:

Optic nerve cupping (80 drugs)

Browse all the conditions that are associated with Optic nerve cupping:

Optic nerve cupping (110 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on calcium (the active ingredients of Calcium citrate) and Calcium citrate (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.