Cannabis and Knee joint replacement - a phase IV clinical study of FDA data

Summary:

Knee joint replacement is reported as a side effect among people who take Cannabis (marijuana), especially for people who are male, 50-59 old, also take Remicade, and have Rheumatoid arthritis.

The phase IV clinical study analyzes which people have Knee joint replacement when taking Cannabis. It is created by eHealthMe based on reports of 12,664 people who have side effects when taking Cannabis from the FDA, and is updated regularly.

What is Cannabis?

Cannabis has active ingredients of marijuana. It is often used in stress and anxiety. eHealthMe is studying from 13,371 Cannabis users. Check the latest studies of Cannabis.

What is Knee joint replacement?

Knee joint replacement is found to be associated with 953 drugs and 1,230 conditions by eHealthMe. Check the latest studies of Knee joint replacement.

On Jul, 24, 2026

12,664 people reported to have side effects when taking Cannabis.
Among them, 69 people (0.54%) have Knee joint replacement.

Could Cannabis cause Knee joint replacement?

Among these 69 people:

What is the gender of people who have Knee joint replacement when taking Cannabis? *

female: 8.47 %
male: 91.53 %

What is the age of people who have Knee joint replacement when taking Cannabis? *

What are other drugs people take besides Cannabis? *

What are other side effects people have besides Knee joint replacement? *

Acute Kidney Failure: 64 people, 92.75%
Thrombosis (formation of a blood clot inside a blood vessel): 64 people, 92.75%
Sepsis (a severe blood infection that can lead to organ failure and death): 64 people, 92.75%
Deep Venous Thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis): 64 people, 92.75%
Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall): 64 people, 92.75%
Joint Swelling: 64 people, 92.75%
Pulmonary Embolism (blockage of the main artery of the lung): 64 people, 92.75%
Heart Attack: 64 people, 92.75%
Terminal State (the transitional states between life and biological death): 63 people, 91.30%
C-Reactive Protein Abnormal: 63 people, 91.30%

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 59 people, 85.51%
Systemic Lupus Erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue): 57 people, 82.61%
Muscle Spasms (muscle contraction): 4 people, 5.80%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 4 people, 5.80%
Hypotonia (low muscle tone): 4 people, 5.80%
Gait Disturbance: 4 people, 5.80%
Rickets (softening of bones): 3 people, 4.35%
Fatigue (feeling of tiredness): 3 people, 4.35%
Rashes (redness): 1 person, 1.45%
Metastatic Malignant Melanoma (spreadable cancer tumour of melanine): 1 person, 1.45%

* Approximation only. Some reports may have incomplete information.

Do you take Cannabis and have Knee joint replacement?

- Check whether Knee joint replacement is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Cannabis:

Cannabis (13,371 reports)

Browse all side effects of Cannabis:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Knee joint replacement:

Knee joint replacement (953 drugs)

Browse all the conditions that are associated with Knee joint replacement:

Knee joint replacement (1,230 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on marijuana (the active ingredients of Cannabis) and Cannabis (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.