Captopril and Knee joint replacement - a phase IV clinical study of FDA data

Summary:

Knee joint replacement is reported as a side effect among people who take Captopril (captopril), especially for people who are female, 60+ old, also take Humira, and have Rheumatoid arthritis.

The phase IV clinical study analyzes which people have Knee joint replacement when taking Captopril. It is created by eHealthMe based on reports of 17,289 people who have side effects when taking Captopril from the FDA, and is updated regularly.

What is Captopril?

Captopril has active ingredients of captopril. It is often used in high blood pressure. eHealthMe is studying from 17,438 Captopril users. Check the latest studies of Captopril.

What is Knee joint replacement?

Knee joint replacement is found to be associated with 954 drugs and 1,228 conditions by eHealthMe. Check the latest studies of Knee joint replacement.

On Jul, 13, 2026

17,289 people reported to have side effects when taking Captopril.
Among them, 14 people (0.08%) have Knee joint replacement.

Could Captopril cause Knee joint replacement?

Among these 14 people:

What is the gender of people who have Knee joint replacement when taking Captopril? *

female: 64.29 %
male: 35.71 %

What is the age of people who have Knee joint replacement when taking Captopril? *

What are other drugs people take besides Captopril? *

What are other side effects people have besides Knee joint replacement? *

Pain: 3 people, 21.43%
Carpal Tunnel Syndrome (nerve compression at wrist results numbness weakness, pain , swelling): 3 people, 21.43%
Chest Pain: 2 people, 14.29%
Finger Deformity (a deformed position of the finger): 2 people, 14.29%
Neck Pain: 2 people, 14.29%
Haematochezia (passage of stools containing blood): 2 people, 14.29%
Mobility Decreased (ability to move is reduced): 2 people, 14.29%
Herpes Zoster: 2 people, 14.29%
Procedural Pain: 2 people, 14.29%
Cough: 2 people, 14.29%

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 8 people, 57.14%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 2 people, 14.29%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 1 person, 7.14%
Psoriasis (immune-mediated disease that affects the skin): 1 person, 7.14%
Pain In Extremity: 1 person, 7.14%
Pain: 1 person, 7.14%
Osteoporosis (bones weak and more likely to break): 1 person, 7.14%
Neuropathy Peripheral (surface nerve damage): 1 person, 7.14%
Musculoskeletal Pain (pain affects the bones, muscles, ligaments, tendons, and nerves): 1 person, 7.14%
Inflammation: 1 person, 7.14%

* Approximation only. Some reports may have incomplete information.

Do you take Captopril and have Knee joint replacement?

- Check whether Knee joint replacement is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Captopril:

Captopril (17,438 reports)

Browse all side effects of Captopril:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Knee joint replacement:

Knee joint replacement (954 drugs)

Browse all the conditions that are associated with Knee joint replacement:

Knee joint replacement (1,228 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on captopril (the active ingredients of Captopril) and Captopril (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.