Captopril and Systemic sclerosis (scleroderma) - a phase IV clinical study of FDA data

Summary:

Systemic sclerosis (scleroderma) is reported as a side effect among people who take Captopril (captopril), especially for people who are female, 60+ old, also take Fosamax, and have Ankylosing spondylitis.

The phase IV clinical study analyzes which people have Systemic sclerosis (scleroderma) when taking Captopril. It is created by eHealthMe based on reports of 17,289 people who have side effects when taking Captopril from the FDA, and is updated regularly.

What is Captopril?

Captopril has active ingredients of captopril. It is often used in high blood pressure. eHealthMe is studying from 17,438 Captopril users. Check the latest studies of Captopril.

What is Systemic sclerosis (scleroderma)?

Systemic sclerosis (scleroderma) (an autoimmune or connective tissue disease. it is characterized by thickening of the skin) is found to be associated with 497 drugs and 857 conditions by eHealthMe. Check the latest studies of Systemic sclerosis (scleroderma).

On Jun, 17, 2026

17,289 people reported to have side effects when taking Captopril.
Among them, 21 people (0.12%) have Systemic sclerosis (scleroderma).

Could Captopril cause Systemic sclerosis (scleroderma)?

Among these 21 people:

What is the gender of people who have Systemic sclerosis (scleroderma) when taking Captopril? *

female: 80.95 %
male: 19.05 %

What is the age of people who have Systemic sclerosis (scleroderma) when taking Captopril? *

What are other drugs people take besides Captopril? *

What are other side effects people have besides Systemic sclerosis (scleroderma)? *

Ards (Acute Respiratory Distress Syndrome) (sudden failure of the respiratory (breathing) system): 6 people, 28.57%
Death: 5 people, 23.81%
Dyspnea (difficult or laboured breathing): 5 people, 23.81%
Pleural Effusion (water on the lungs): 4 people, 19.05%
Fever: 4 people, 19.05%
Pericardial Effusion (fluid around the heart): 4 people, 19.05%
Thrombocytopenia (decrease of platelets in blood): 4 people, 19.05%
Dyspnea Exacerbated: 3 people, 14.29%
Pain In Extremity: 3 people, 14.29%
Weight Decreased: 3 people, 14.29%

What are the existing conditions these people have? *

Joint Pain: 2 people, 9.52%
Depression: 2 people, 9.52%
Ankylosing Spondylitis (type of arthritis affecting the spine): 2 people, 9.52%
Type 1 Diabetes: 1 person, 4.76%
Systemic Sclerosis (an autoimmune or connective tissue disease. it is characterized by thickening of the skin): 1 person, 4.76%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 1 person, 4.76%
Pulmonary Hypertension (increase in blood pressure in the lung artery): 1 person, 4.76%
Psoriasis (immune-mediated disease that affects the skin): 1 person, 4.76%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 1 person, 4.76%
Diabetes: 1 person, 4.76%

* Approximation only. Some reports may have incomplete information.

Do you take Captopril and have Systemic sclerosis (scleroderma)?

- Check whether Systemic sclerosis (scleroderma) is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Captopril:

Captopril (17,438 reports)

Browse all side effects of Captopril:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Systemic sclerosis (scleroderma):

Systemic sclerosis (scleroderma) (497 drugs)

Browse all the conditions that are associated with Systemic sclerosis (scleroderma):

Systemic sclerosis (scleroderma) (857 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on captopril (the active ingredients of Captopril) and Captopril (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.