Carpine and Fluid retention - a phase IV clinical study of FDA data

Summary:

Fluid retention is reported as a side effect among people who take Carpine (pilocarpine hydrochloride), especially for people who are female, 60+ old, also take Amlodipine, and have Pain.

The phase IV clinical study analyzes which people have Fluid retention when taking Carpine. It is created by eHealthMe based on reports of 5,521 people who have side effects when taking Carpine from the FDA, and is updated regularly.

What is Carpine?

Carpine has active ingredients of pilocarpine hydrochloride. eHealthMe is studying from 5,561 Carpine users. Check the latest studies of Carpine.

What is Fluid retention?

Fluid retention (an abnormal accumulation of fluid in the blood) is found to be associated with 1,698 drugs and 2,448 conditions by eHealthMe. Check the latest studies of Fluid retention.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

5,521 people reported to have side effects when taking Carpine.
Among them, 17 people (0.31%) have Fluid retention.

Among these 17 people:

What is the gender of people who have Fluid retention when taking Carpine? *

female: 76.47 %
male: 23.53 %

What is the age of people who have Fluid retention when taking Carpine? *

What are other drugs people take besides Carpine? *

What are other side effects people have besides Fluid retention? *

Weight Increased: 8 people, 47.06%
Back Pain: 3 people, 17.65%
Fatigue (feeling of tiredness): 3 people, 17.65%
Fall: 3 people, 17.65%
Dyspnea (difficult or laboured breathing): 3 people, 17.65%
Drug Ineffective: 3 people, 17.65%
Pain: 3 people, 17.65%
Aneurysm (enlargement of an artery caused by a weakening of the artery wall): 2 people, 11.76%
Gait Disturbance: 2 people, 11.76%
Pain In Extremity: 2 people, 11.76%

What are the existing conditions these people have? *

Pulmonary Hypertension (increase in blood pressure in the lung artery): 5 people, 29.41%
Pain: 5 people, 29.41%
Neuralgia (pain in one or more nerves): 4 people, 23.53%
Depression: 4 people, 23.53%
Nervousness: 3 people, 17.65%
Dyspnea (difficult or laboured breathing): 3 people, 17.65%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 17.65%
Arterial Disorder: 2 people, 11.76%
Blood Disorder: 2 people, 11.76%
Coronary Artery Occlusion (complete obstruction of blood flow in a coronary artery): 2 people, 11.76%

* Approximation only. Some reports may have incomplete information.

Do you take Carpine and have Fluid retention?

- Check whether Fluid retention is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Carpine:

Carpine (5,561 reports)

Fluid retention treatments and more:

Fluid retention (79,661 reports)

Browse all side effects of Carpine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Fluid retention:

Fluid retention (1,698 drugs)

Browse all the conditions that are associated with Fluid retention:

Fluid retention (2,448 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on pilocarpine hydrochloride (the active ingredients of Carpine) and Carpine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.