Cefuroxime and Pyroglutamate increased - a phase IV clinical study of FDA data

Summary:

Pyroglutamate increased is reported as a side effect among people who take Cefuroxime (cefuroxime sodium), especially for people who are female, 60+ old, also take Acetaminophen, and have Sepsis.

The phase IV clinical study analyzes which people have Pyroglutamate increased when taking Cefuroxime. It is created by eHealthMe based on reports of 12,808 people who have side effects when taking Cefuroxime from the FDA, and is updated regularly.

What is Cefuroxime?

Cefuroxime has active ingredients of cefuroxime sodium. It is often used in sinusitis. eHealthMe is studying from 12,999 Cefuroxime users. Check the latest studies of Cefuroxime.

What is Pyroglutamate increased?

Pyroglutamate increased is found to be associated with 15 drugs and 39 conditions by eHealthMe. Check the latest studies of Pyroglutamate increased.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

12,808 people reported to have side effects when taking Cefuroxime.
Among them, 12 people (0.09%) have Pyroglutamate increased.

Could Cefuroxime cause Pyroglutamate increased?

Among these 12 people:

What is the gender of people who have Pyroglutamate increased when taking Cefuroxime? *

female: 100 %
male: 0.0 %

What is the age of people who have Pyroglutamate increased when taking Cefuroxime? *

What are other drugs people take besides Cefuroxime? *

Acetaminophen: 11 people, 91.67%
Paracetamol: 1 person, 8.33%

What are other side effects people have besides Pyroglutamate increased? *

Metabolic Acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body): 12 people, 100.00%
Hypokalemia (low potassium): 6 people, 50.00%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 4 people, 33.33%
Renal Impairment (severely reduced kidney function): 3 people, 25.00%
Staphylococcal Sepsis (blood infection by an infection with staphylococcus bacteria): 2 people, 16.67%
Enterococcal Infection: 2 people, 16.67%
Arthritis Infective (purulent invasion of a joint by an infectious agent which produces arthritis): 2 people, 16.67%
Sepsis (a severe blood infection that can lead to organ failure and death): 1 person, 8.33%
Postoperative Wound Infection: 1 person, 8.33%

What are the existing conditions these people have? *

Sepsis (a severe blood infection that can lead to organ failure and death): 9 people, 75.00%
Wound Complication: 3 people, 25.00%
Procedural Pain: 3 people, 25.00%
Joint Pain: 2 people, 16.67%
Femoral Neck Fracture (neck of femur bone fracture): 2 people, 16.67%
Wound Infection: 1 person, 8.33%
Staphylococcal Infection (an infection with staphylococcus bacteria): 1 person, 8.33%
Postoperative Abscess: 1 person, 8.33%

* Approximation only. Some reports may have incomplete information.

Do you take Cefuroxime and have Pyroglutamate increased?

- Check whether Pyroglutamate increased is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Cefuroxime:

Cefuroxime (12,999 reports)

Browse all side effects of Cefuroxime:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Pyroglutamate increased:

Pyroglutamate increased (15 drugs)

Browse all the conditions that are associated with Pyroglutamate increased:

Pyroglutamate increased (39 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on cefuroxime sodium (the active ingredients of Cefuroxime) and Cefuroxime (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.