Celebrex and Polysubstance dependence - a phase IV clinical study of FDA data

Summary:

Polysubstance dependence is reported as a side effect among people who take Celebrex (celecoxib), especially for people who are male, 60+ old, also take Klonopin, and have Stress and anxiety.

The phase IV clinical study analyzes which people have Polysubstance dependence when taking Celebrex. It is created by eHealthMe based on reports of 147,540 people who have side effects when taking Celebrex from the FDA, and is updated regularly.

What is Celebrex?

Celebrex has active ingredients of celecoxib. It is often used in arthritis. eHealthMe is studying from 151,105 Celebrex users. Check the latest studies of Celebrex.

What is Polysubstance dependence?

Polysubstance dependence is found to be associated with 50 drugs and 96 conditions by eHealthMe. Check the latest studies of Polysubstance dependence.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 24, 2026

147,540 people reported to have side effects when taking Celebrex.
Among them, 15 people (0.01%) have Polysubstance dependence.

Could Celebrex cause Polysubstance dependence?

Among these 15 people:

What is the gender of people who have Polysubstance dependence when taking Celebrex? *

female: 40 %
male: 60 %

What is the age of people who have Polysubstance dependence when taking Celebrex? *

What are other drugs people take besides Celebrex? *

What are other side effects people have besides Polysubstance dependence? *

Back Pain: 10 people, 66.67%
Insomnia (sleeplessness): 9 people, 60.00%
Drug Dependence: 9 people, 60.00%
Drug Withdrawal Syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation): 8 people, 53.33%
Chest Pain: 7 people, 46.67%
Major Depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings): 7 people, 46.67%
Headache (pain in head): 7 people, 46.67%
Nausea (feeling of having an urge to vomit): 7 people, 46.67%
Nausea And Vomiting: 7 people, 46.67%
Nervousness: 6 people, 40.00%

What are the existing conditions these people have? *

Stress And Anxiety: 7 people, 46.67%
Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 6 people, 40.00%
Postpartum Depression (depression suffered by a mother following childbirth): 6 people, 40.00%
High Blood Pressure: 6 people, 40.00%
Diabetes: 6 people, 40.00%
Sleep Disorder: 1 person, 6.67%
Pain Exacerbated: 1 person, 6.67%
Nervous System Disorder (a general class of medical conditions affecting the nervous system): 1 person, 6.67%
Insomnia (sleeplessness): 1 person, 6.67%
Agitation (state of anxiety or nervous excitement): 1 person, 6.67%

* Approximation only. Some reports may have incomplete information.

Do you take Celebrex and have Polysubstance dependence?

- Check whether Polysubstance dependence is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Celebrex:

Celebrex (151,105 reports)

Browse all side effects of Celebrex:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Polysubstance dependence:

Polysubstance dependence (50 drugs)

Browse all the conditions that are associated with Polysubstance dependence:

Polysubstance dependence (96 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on celecoxib (the active ingredients of Celebrex) and Celebrex (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.