Centrum and Calcium deficiency - a phase IV clinical study of FDA data

Summary:

Calcium deficiency is reported as a side effect among people who take Centrum (ascorbic acid; biotin; cyanocobalamin; dexpanthenol; ergocalciferol; folic acid; niacinamide; pyridoxine hydrochloride; riboflavin phosphate sodium; thiamine hydrochloride; vitamin a; vitamin e), especially for people who are female, 60+ old, also take Fosamax, and have Osteoporosis.

The phase IV clinical study analyzes which people have Calcium deficiency when taking Centrum. It is created by eHealthMe based on reports of 33,642 people who have side effects when taking Centrum from the FDA, and is updated regularly.

What is Centrum?

Centrum has active ingredients of ascorbic acid; biotin; cyanocobalamin; dexpanthenol; ergocalciferol; folic acid; niacinamide; pyridoxine hydrochloride; riboflavin phosphate sodium; thiamine hydrochloride; vitamin a; vitamin e. It is often used in vitamin supplementation. eHealthMe is studying from 34,686 Centrum users. Check the latest studies of Centrum.

What is Calcium deficiency?

Calcium deficiency (lack of calcium) is found to be associated with 254 drugs and 764 conditions by eHealthMe. Check the latest studies of Calcium deficiency.

On Aug, 05, 2026

33,642 people reported to have side effects when taking Centrum.
Among them, 21 people (0.06%) have Calcium deficiency.

Among these 21 people:

What is the gender of people who have Calcium deficiency when taking Centrum? *

female: 100 %
male: 0.0 %

What is the age of people who have Calcium deficiency when taking Centrum? *

What are other drugs people take besides Centrum? *

Fosamax: 15 people, 71.43%
Alendronate Sodium: 5 people, 23.81%
Actonel: 4 people, 19.05%
Celexa: 4 people, 19.05%
Nexium: 3 people, 14.29%
Premarin: 3 people, 14.29%
Omega-3 Marine Triglycerides: 2 people, 9.52%
Hydrochlorothiazide: 2 people, 9.52%
Prevacid: 2 people, 9.52%
Fentanyl: 1 person, 4.76%

What are other side effects people have besides Calcium deficiency? *

Femur Fracture: 15 people, 71.43%
Fall: 15 people, 71.43%
Low Turnover Osteopathy (slow removal of old bone and its replacement by new bone): 12 people, 57.14%
Stress And Anxiety: 12 people, 57.14%
Osteoporosis (bones weak and more likely to break): 10 people, 47.62%
Pneumonia: 10 people, 47.62%
Rickets (softening of bones): 10 people, 47.62%
Depression: 9 people, 42.86%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 9 people, 42.86%
Broken Bone: 8 people, 38.10%

What are the existing conditions these people have? *

Osteoporosis (bones weak and more likely to break): 11 people, 52.38%
Osteopenia (a condition where bone mineral density is lower than normal): 6 people, 28.57%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 19.05%
Indigestion: 2 people, 9.52%
Multiple Allergies (allergy to multiple agents): 2 people, 9.52%
Broken Bone: 2 people, 9.52%
High Blood Cholesterol: 1 person, 4.76%
Gastric Ulcer (stomach ulcer): 1 person, 4.76%
Ear Pain: 1 person, 4.76%
Diarrhea: 1 person, 4.76%

* Approximation only. Some reports may have incomplete information.

Do you take Centrum and have Calcium deficiency?

- Check whether Calcium deficiency is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Centrum:

Centrum (34,686 reports)

Calcium deficiency treatments and more:

Calcium deficiency (3,751 reports)

How severe was Calcium deficiency and when was it recovered:

Calcium deficiency in Centrum

Expand to all the drugs that have ingredients of ascorbic acid; biotin; cyanocobalamin; dexpanthenol; ergocalciferol; folic acid; niacinamide; pyridoxine hydrochloride; riboflavin phosphate sodium; thiamine hydrochloride; vitamin a; vitamin e:

Calcium deficiency and drugs with ingredients of ascorbic acid; biotin; cyanocobalamin; dexpanthenol; ergocalciferol; folic acid; niacinamide; pyridoxine hydrochloride; riboflavin phosphate sodium; thiamine hydrochloride; vitamin a; vitamin e (253 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Centrum:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Calcium deficiency:

Calcium deficiency (254 drugs)

Browse all the conditions that are associated with Calcium deficiency:

Calcium deficiency (764 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on ascorbic acid; biotin; cyanocobalamin; dexpanthenol; ergocalciferol; folic acid; niacinamide; pyridoxine hydrochloride; riboflavin phosphate sodium; thiamine hydrochloride; vitamin a; vitamin e (the active ingredients of Centrum) and Centrum (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.