Centrum and Ddd - a phase IV clinical study of FDA data

Summary:

Ddd is reported as a side effect among people who take Centrum (ascorbic acid; biotin; cyanocobalamin; dexpanthenol; ergocalciferol; folic acid; niacinamide; pyridoxine hydrochloride; riboflavin phosphate sodium; thiamine hydrochloride; vitamin a; vitamin e), especially for people who are female, 60+ old, also take Zometa, and have Osteoporosis.

The phase IV clinical study analyzes which people have Ddd when taking Centrum. It is created by eHealthMe based on reports of 33,642 people who have side effects when taking Centrum from the FDA, and is updated regularly.

What is Centrum?

Centrum has active ingredients of ascorbic acid; biotin; cyanocobalamin; dexpanthenol; ergocalciferol; folic acid; niacinamide; pyridoxine hydrochloride; riboflavin phosphate sodium; thiamine hydrochloride; vitamin a; vitamin e. It is often used in vitamin supplementation. eHealthMe is studying from 34,683 Centrum users. Check the latest studies of Centrum.

What is Ddd?

Ddd is found to be associated with 1,387 drugs and 1,394 conditions by eHealthMe. Check the latest studies of Ddd.

On Nov, 04, 2025

33,642 people reported to have side effects when taking Centrum.
Among them, 198 people (0.59%) have Ddd.

Among these 198 people:

* Approximation only. Some reports may have incomplete information.

Do you take Centrum and have Ddd?

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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Centrum:

Centrum (34,683 reports)

Ddd treatments and more:

Ddd (19,906 reports)

How severe was Ddd and when was it recovered:

Ddd in Centrum

Expand to all the drugs that have ingredients of ascorbic acid; biotin; cyanocobalamin; dexpanthenol; ergocalciferol; folic acid; niacinamide; pyridoxine hydrochloride; riboflavin phosphate sodium; thiamine hydrochloride; vitamin a; vitamin e:

Ddd and drugs with ingredients of ascorbic acid; biotin; cyanocobalamin; dexpanthenol; ergocalciferol; folic acid; niacinamide; pyridoxine hydrochloride; riboflavin phosphate sodium; thiamine hydrochloride; vitamin a; vitamin e (1,317 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Common Centrum side effects:

Browse all side effects of Centrum:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Common drugs associated with Ddd:

Fosamax side effect: Ddd (3,043 reports)
Zometa side effect: Ddd (2,149 reports)
Prednisone side effect: Ddd (1,905 reports)
Aspirin side effect: Ddd (1,557 reports)
Humira side effect: Ddd (1,378 reports)
Aredia side effect: Ddd (1,331 reports)
Gabapentin side effect: Ddd (1,253 reports)
Methotrexate side effect: Ddd (1,183 reports)
Vioxx side effect: Ddd (1,069 reports)
Celebrex side effect: Ddd (1,050 reports)

Browse all the drugs that are associated with Ddd:

Ddd (1,387 drugs)

Common conditions associated with Ddd:

Osteoporosis: 2,599 reports
Thin bones: 2,465 reports
Rheumatoid arthritis: 1,738 reports
Osteopenia: 1,259 reports
Pain exacerbated: 1,225 reports
Alternative medicine - pain relief: 1,223 reports
Hypertension aggravated: 1,034 reports
Hypertension: 1,031 reports
Ms hug: 1,020 reports
Acupuncture and pain: 831 reports

Browse all the conditions that are associated with Ddd:

Ddd (1,394 conditions)

Drugs similar to Centrum and Ddd :

Vitamin d side effect: Ddd

How the study uses the data?

The study uses data from the FDA. It is based on ascorbic acid; biotin; cyanocobalamin; dexpanthenol; ergocalciferol; folic acid; niacinamide; pyridoxine hydrochloride; riboflavin phosphate sodium; thiamine hydrochloride; vitamin a; vitamin e (the active ingredients of Centrum) and Centrum (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.