Centrum and Splenomegaly - a phase IV clinical study of FDA data

Summary:

Splenomegaly is reported as a side effect among people who take Centrum (ascorbic acid; biotin; cyanocobalamin; dexpanthenol; ergocalciferol; folic acid; niacinamide; pyridoxine hydrochloride; riboflavin phosphate sodium; thiamine hydrochloride; vitamin a; vitamin e), especially for people who are male, 60+ old, also take Jakafi, and have Primary myelofibrosis.

The phase IV clinical study analyzes which people have Splenomegaly when taking Centrum. It is created by eHealthMe based on reports of 33,642 people who have side effects when taking Centrum from the FDA, and is updated regularly.

What is Centrum?

Centrum has active ingredients of ascorbic acid; biotin; cyanocobalamin; dexpanthenol; ergocalciferol; folic acid; niacinamide; pyridoxine hydrochloride; riboflavin phosphate sodium; thiamine hydrochloride; vitamin a; vitamin e. It is often used in vitamin supplementation. eHealthMe is studying from 34,686 Centrum users. Check the latest studies of Centrum.

What is Splenomegaly?

Splenomegaly (enlargement of spleen) is found to be associated with 1,121 drugs and 1,477 conditions by eHealthMe. Check the latest studies of Splenomegaly.

On Jul, 13, 2026

33,642 people reported to have side effects when taking Centrum.
Among them, 78 people (0.23%) have Splenomegaly.

Among these 78 people:

What is the gender of people who have Splenomegaly when taking Centrum? *

female: 31.71 %
male: 68.29 %

What is the age of people who have Splenomegaly when taking Centrum? *

What are other drugs people take besides Centrum? *

What are other side effects people have besides Splenomegaly? *

Thrombocytopenia (decrease of platelets in blood): 39 people, 50.00%
Diarrhea: 32 people, 41.03%
Head Injury: 29 people, 37.18%
Abdominal Pain: 27 people, 34.62%
Haemoglobin Decreased: 27 people, 34.62%
Back Pain: 23 people, 29.49%
Weight Decreased: 22 people, 28.21%
Anaemia (lack of blood): 21 people, 26.92%
Dyspnea (difficult or laboured breathing): 19 people, 24.36%
Fever: 19 people, 24.36%

What are the existing conditions these people have? *

Primary Myelofibrosis (primary disorder of the bone marrow): 33 people, 42.31%
Pain: 8 people, 10.26%
Polycythaemia Vera (blood disorder in which the bone marrow makes too many red blood cells): 7 people, 8.97%
Breast Cancer: 6 people, 7.69%
Non-Hodgkin's Lymphoma (malignant (cancer) cells form in the lymph system): 6 people, 7.69%
Multiple Myeloma (cancer of the plasma cells): 5 people, 6.41%
Malignant Melanoma (skin cancer rises from melancytes): 3 people, 3.85%
Dizziness: 3 people, 3.85%
Nausea (feeling of having an urge to vomit): 2 people, 2.56%
Joint Pain: 2 people, 2.56%

* Approximation only. Some reports may have incomplete information.

Do you take Centrum and have Splenomegaly?

- Check whether Splenomegaly is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Centrum:

Centrum (34,686 reports)

Splenomegaly treatments and more:

Splenomegaly (17,257 reports)

How severe was Splenomegaly and when was it recovered:

Splenomegaly in Centrum

Expand to all the drugs that have ingredients of ascorbic acid; biotin; cyanocobalamin; dexpanthenol; ergocalciferol; folic acid; niacinamide; pyridoxine hydrochloride; riboflavin phosphate sodium; thiamine hydrochloride; vitamin a; vitamin e:

Splenomegaly and drugs with ingredients of ascorbic acid; biotin; cyanocobalamin; dexpanthenol; ergocalciferol; folic acid; niacinamide; pyridoxine hydrochloride; riboflavin phosphate sodium; thiamine hydrochloride; vitamin a; vitamin e (664 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Centrum:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Splenomegaly:

Splenomegaly (1,120 drugs)

Browse all the conditions that are associated with Splenomegaly:

Splenomegaly (1,477 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on ascorbic acid; biotin; cyanocobalamin; dexpanthenol; ergocalciferol; folic acid; niacinamide; pyridoxine hydrochloride; riboflavin phosphate sodium; thiamine hydrochloride; vitamin a; vitamin e (the active ingredients of Centrum) and Centrum (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.