Centrum and Vulvovaginal dryness - a phase IV clinical study of FDA data

Summary:

Vulvovaginal dryness is reported as a side effect among people who take Centrum (ascorbic acid; biotin; cyanocobalamin; dexpanthenol; ergocalciferol; folic acid; niacinamide; pyridoxine hydrochloride; riboflavin phosphate sodium; thiamine hydrochloride; vitamin a; vitamin e), especially for people who are 50-59 old, also take Fosamax, and have Osteoporosis.

The phase IV clinical study analyzes which people have Vulvovaginal dryness when taking Centrum. It is created by eHealthMe based on reports of 33,642 people who have side effects when taking Centrum from the FDA, and is updated regularly.

What is Centrum?

Centrum has active ingredients of ascorbic acid; biotin; cyanocobalamin; dexpanthenol; ergocalciferol; folic acid; niacinamide; pyridoxine hydrochloride; riboflavin phosphate sodium; thiamine hydrochloride; vitamin a; vitamin e. It is often used in vitamin supplementation. eHealthMe is studying from 34,686 Centrum users. Check the latest studies of Centrum.

What is Vulvovaginal dryness?

Vulvovaginal dryness is found to be associated with 436 drugs and 517 conditions by eHealthMe. Check the latest studies of Vulvovaginal dryness.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 30, 2026

33,642 people reported to have side effects when taking Centrum.
Among them, 37 people (0.11%) have Vulvovaginal dryness.

Could Centrum cause Vulvovaginal dryness?

Among these 37 people:

What is the age of people who have Vulvovaginal dryness when taking Centrum? *

What are other drugs people take besides Centrum? *

What are other side effects people have besides Vulvovaginal dryness? *

Gastrointestinal Disorder (functional problems of gastrointestinal tract): 21 people, 56.76%
Stress And Anxiety: 21 people, 56.76%
Low Turnover Osteopathy (slow removal of old bone and its replacement by new bone): 20 people, 54.05%
Femur Fracture: 20 people, 54.05%
Foot Deformity (functional disability of foot): 20 people, 54.05%
Nasopharyngitis (inflammation of the nasopharynx): 17 people, 45.95%
Hot Flush (sudden feelings of heat): 17 people, 45.95%
Broken Bone: 17 people, 45.95%
Pain: 17 people, 45.95%
Osteoporosis (bones weak and more likely to break): 16 people, 43.24%

What are the existing conditions these people have? *

Osteoporosis (bones weak and more likely to break): 21 people, 56.76%
Osteopenia (a condition where bone mineral density is lower than normal): 17 people, 45.95%
Breast Cancer: 4 people, 10.81%
Vulvovaginal Pain: 3 people, 8.11%
Diabetes: 3 people, 8.11%
Tinnitus (a ringing in the ears): 3 people, 8.11%
High Blood Pressure: 3 people, 8.11%
Thyroid Diseases: 3 people, 8.11%
Pain: 2 people, 5.41%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 2 people, 5.41%

* Approximation only. Some reports may have incomplete information.

Do you take Centrum and have Vulvovaginal dryness?

- Check whether Vulvovaginal dryness is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Centrum:

Centrum (34,686 reports)

Vulvovaginal dryness treatments and more:

Vulvovaginal dryness (9,757 reports)

How severe was Vulvovaginal dryness and when was it recovered:

Vulvovaginal dryness in Centrum

Expand to all the drugs that have ingredients of ascorbic acid; biotin; cyanocobalamin; dexpanthenol; ergocalciferol; folic acid; niacinamide; pyridoxine hydrochloride; riboflavin phosphate sodium; thiamine hydrochloride; vitamin a; vitamin e:

Vulvovaginal dryness and drugs with ingredients of ascorbic acid; biotin; cyanocobalamin; dexpanthenol; ergocalciferol; folic acid; niacinamide; pyridoxine hydrochloride; riboflavin phosphate sodium; thiamine hydrochloride; vitamin a; vitamin e (187 reports)

Sub-studies by age:

0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Centrum:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Vulvovaginal dryness:

Vulvovaginal dryness (436 drugs)

Browse all the conditions that are associated with Vulvovaginal dryness:

Vulvovaginal dryness (517 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on ascorbic acid; biotin; cyanocobalamin; dexpanthenol; ergocalciferol; folic acid; niacinamide; pyridoxine hydrochloride; riboflavin phosphate sodium; thiamine hydrochloride; vitamin a; vitamin e (the active ingredients of Centrum) and Centrum (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.