Chlorthalidone and Aortic aneurysm - a phase IV clinical study of FDA data

Summary:

Aortic aneurysm is reported as a side effect among people who take Chlorthalidone (chlorthalidone), especially for people who are male, 60+ old, also take Aspirin, and have Carcinoid tumor.

The phase IV clinical study analyzes which people have Aortic aneurysm when taking Chlorthalidone. It is created by eHealthMe based on reports of 11,957 people who have side effects when taking Chlorthalidone from the FDA, and is updated regularly.

What is Chlorthalidone?

Chlorthalidone has active ingredients of chlorthalidone. It is often used in high blood pressure. eHealthMe is studying from 12,482 Chlorthalidone users. Check the latest studies of Chlorthalidone.

What is Aortic aneurysm?

Aortic aneurysm (enlargement of an aortic artery caused by a weakening of the artery wall) is found to be associated with 748 drugs and 840 conditions by eHealthMe. Check the latest studies of Aortic aneurysm.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 14, 2026

11,957 people reported to have side effects when taking Chlorthalidone.
Among them, 16 people (0.13%) have Aortic aneurysm.

Could Chlorthalidone cause Aortic aneurysm?

Among these 16 people:

What is the gender of people who have Aortic aneurysm when taking Chlorthalidone? *

female: 37.5 %
male: 62.5 %

What is the age of people who have Aortic aneurysm when taking Chlorthalidone? *

What are other drugs people take besides Chlorthalidone? *

What are other side effects people have besides Aortic aneurysm? *

Abdominal Discomfort: 7 people, 43.75%
Blood Pressure Systolic Increased: 7 people, 43.75%
Head Injury: 5 people, 31.25%
Fatigue (feeling of tiredness): 5 people, 31.25%
Pain: 5 people, 31.25%
Discomfort: 4 people, 25.00%
Injection Site Haemorrhage (bleeding from injection site): 4 people, 25.00%
Malaise (a feeling of general discomfort or uneasiness): 4 people, 25.00%
Malignant Neoplasm Progression (cancer tumour came back): 4 people, 25.00%
Hepatic Neoplasm (liver tumour): 4 people, 25.00%

What are the existing conditions these people have? *

Carcinoid Tumor: 4 people, 25.00%
Primary Immunodeficiency Syndrome: 3 people, 18.75%
Myelodysplastic Syndrome (a group of conditions that occur when the blood-forming cells in the bone marrow are damaged): 3 people, 18.75%
Immunodeficiency Common Variable: 3 people, 18.75%
Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection): 3 people, 18.75%
Pain: 2 people, 12.50%
Rhabdomyosarcoma (cancer of the bone, soft tissues, or connective tissue (e.g., tendon or cartilage)): 1 person, 6.25%
Haemoglobin Decreased: 1 person, 6.25%
Erection Problems: 1 person, 6.25%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 1 person, 6.25%

* Approximation only. Some reports may have incomplete information.

Do you take Chlorthalidone and have Aortic aneurysm?

- Check whether Aortic aneurysm is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Chlorthalidone:

Chlorthalidone (12,482 reports)

Aortic aneurysm treatments and more:

Aortic aneurysm (10,466 reports)

Browse all side effects of Chlorthalidone:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Aortic aneurysm:

Aortic aneurysm (748 drugs)

Browse all the conditions that are associated with Aortic aneurysm:

Aortic aneurysm (840 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on chlorthalidone (the active ingredients of Chlorthalidone) and Chlorthalidone (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.