Chlorthalidone and Hypothyroidism - a phase IV clinical study of FDA data

Summary:

Hypothyroidism is reported as a side effect among people who take Chlorthalidone (chlorthalidone), especially for people who are female, 60+ old, also take Amlodipine, and have Asthma.

The phase IV clinical study analyzes which people have Hypothyroidism when taking Chlorthalidone. It is created by eHealthMe based on reports of 11,957 people who have side effects when taking Chlorthalidone from the FDA, and is updated regularly.

What is Chlorthalidone?

Chlorthalidone has active ingredients of chlorthalidone. It is often used in high blood pressure. eHealthMe is studying from 12,482 Chlorthalidone users. Check the latest studies of Chlorthalidone.

What is Hypothyroidism?

Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development) is found to be associated with 1,617 drugs and 2,600 conditions by eHealthMe. Check the latest studies of Hypothyroidism.

On May, 11, 2026

11,957 people reported to have side effects when taking Chlorthalidone.
Among them, 76 people (0.64%) have Hypothyroidism.

Could Chlorthalidone cause Hypothyroidism?

Among these 76 people:

What is the gender of people who have Hypothyroidism when taking Chlorthalidone? *

female: 87.5 %
male: 12.5 %

What is the age of people who have Hypothyroidism when taking Chlorthalidone? *

What are other drugs people take besides Chlorthalidone? *

What are other side effects people have besides Hypothyroidism? *

Fatigue (feeling of tiredness): 32 people, 42.11%
Anaemia (lack of blood): 32 people, 42.11%
Headache (pain in head): 31 people, 40.79%
Sepsis (a severe blood infection that can lead to organ failure and death): 30 people, 39.47%
Heart Attack: 30 people, 39.47%
Pulmonary Oedema (fluid accumulation in the lungs): 29 people, 38.16%
Weight Decreased: 29 people, 38.16%
Orthostatic Hypotension (a medical condition consisting of a sudden decrease in blood pressure when a person stands up): 28 people, 36.84%
Peripheral Swelling: 28 people, 36.84%
Hyperthyroidism (over activity of the thyroid gland): 26 people, 34.21%

What are the existing conditions these people have? *

Asthma: 34 people, 44.74%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 7 people, 9.21%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 7 people, 9.21%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 7 people, 9.21%
Pain: 6 people, 7.89%
Neuralgia (pain in one or more nerves): 6 people, 7.89%
Drowsiness: 5 people, 6.58%
Type 2 Diabetes: 4 people, 5.26%
Cough: 3 people, 3.95%
Renal Cell Carcinoma (a kidney cancer): 2 people, 2.63%

* Approximation only. Some reports may have incomplete information.

Do you take Chlorthalidone and have Hypothyroidism?

- Check whether Hypothyroidism is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Chlorthalidone:

Chlorthalidone (12,482 reports)

Hypothyroidism treatments and more:

Hypothyroidism (168,067 reports)

Browse all side effects of Chlorthalidone:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hypothyroidism:

Hypothyroidism (1,617 drugs)

Browse all the conditions that are associated with Hypothyroidism:

Hypothyroidism (2,600 conditions)

Related publications that referenced our studies

Ezeji GC, Inoue T, Bahtiyar G, Sacerdote A, "Hallucinations associated with miglitol use in a patient with chronic kidney disease and hypothyroidism", BMJ case reports, 2015 Feb .
Ezeji GC, Inoue T, Bahtiyar G, Sacerdote A, "Hallucinations associated with miglitol use in a patient with chronic kidney disease and hypothyroidism", BMJ case reports, 2015 Feb .

How the study uses the data?

The study uses data from the FDA. It is based on chlorthalidone (the active ingredients of Chlorthalidone) and Chlorthalidone (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.