Citicoline and Fatigue - a phase IV clinical study of FDA data

Summary:

Fatigue is reported as a side effect among people who take Citicoline (citicoline), especially for people who are male, 60+ old, have been taking the drug for 1 - 6 months also take Sertraline, and have High blood pressure.

The phase IV clinical study analyzes which people have Fatigue when taking Citicoline. It is created by eHealthMe based on reports of 479 people who have side effects when taking Citicoline from the FDA, and is updated regularly.

What is Citicoline?

Citicoline has active ingredients of citicoline. eHealthMe is studying from 508 Citicoline users. Check the latest studies of Citicoline.

What is Fatigue?

Fatigue (feeling of tiredness) is found to be associated with 4,027 drugs and 6,382 conditions by eHealthMe. Check the latest studies of Fatigue.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

479 people reported to have side effects when taking Citicoline.
Among them, 61 people (12.73%) have Fatigue.

Among these 61 people:

How long have people been on Citicoline when they have Fatigue? *

What is the gender of people who have Fatigue when taking Citicoline? *

female: 3.7 %
male: 96.3 %

What is the age of people who have Fatigue when taking Citicoline? *

What are other drugs people take besides Citicoline? *

What are other side effects people have besides Fatigue? *

High Blood Cholesterol: 55 people, 90.16%
Hyperglycemia (high blood sugar): 55 people, 90.16%
High Blood Pressure: 51 people, 83.61%
Overdose: 45 people, 73.77%
Malignant Hypertension (Arteriolar Nephrosclerosis) (a medical condition where the blood pressure of the patient suddenly reaches extremely high): 8 people, 13.11%
Malaise (a feeling of general discomfort or uneasiness): 3 people, 4.92%
Hypotension (abnormally low blood pressure): 2 people, 3.28%
Ards (Acute Respiratory Distress Syndrome) (sudden failure of the respiratory (breathing) system): 2 people, 3.28%
Drug Eruption (adverse drug reaction of the skin): 2 people, 3.28%
Haemoglobin Decreased: 2 people, 3.28%

What are the existing conditions these people have? *

High Blood Pressure: 57 people, 93.44%
Insomnia (sleeplessness): 56 people, 91.80%
Diabetes: 55 people, 90.16%
Enlarged Prostate: 55 people, 90.16%
High Blood Cholesterol: 55 people, 90.16%
Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures): 54 people, 88.52%
Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 3 people, 4.92%
Abnormal Behavior: 3 people, 4.92%
Gastric Mucosal Lesion (lesion of stomach mucous membrane): 3 people, 4.92%
Hepatitis C: 2 people, 3.28%

* Approximation only. Some reports may have incomplete information.

Do you take Citicoline and have Fatigue?

- Check whether Fatigue is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Citicoline:

Citicoline (508 reports)

Fatigue treatments and more:

Fatigue (967,543 reports)

Browse all side effects of Citicoline:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Fatigue:

Fatigue (4,027 drugs)

Browse all the conditions that are associated with Fatigue:

Fatigue (6,382 conditions)

Related publications that referenced our studies

Peel MM, Cooke M, Lewis-Peel HJ, Lea RA, Moyle W, "A randomized controlled trial of coenzyme Q 10 for fatigue in the late-onset sequelae of poliomyelitis", Complementary therapies in medicine, 2015 Dec .
Peel MM, Cooke M, Lewis-Peel HJ, Lea RA, Moyle W, "A randomized controlled trial of coenzyme Q 10 for fatigue in the late-onset sequelae of poliomyelitis", Complementary therapies in medicine, 2015 Dec .

How the study uses the data?

The study uses data from the FDA. It is based on citicoline (the active ingredients of Citicoline) and Citicoline (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.