Citrus and Fatigue - a phase IV clinical study of FDA data

Summary:

Fatigue is reported as a side effect among people who take Citrus (grapefruit), especially for people who are female, 60+ old, also take Vitamin C, and have Ovarian cancer.

The phase IV clinical study analyzes which people have Fatigue when taking Citrus. It is created by eHealthMe based on reports of 177 people who have side effects when taking Citrus from the FDA, and is updated regularly.

What is Citrus?

Citrus has active ingredients of grapefruit. eHealthMe is studying from 201 Citrus users. Check the latest studies of Citrus.

What is Fatigue?

Fatigue (feeling of tiredness) is found to be associated with 4,027 drugs and 6,382 conditions by eHealthMe. Check the latest studies of Fatigue.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

177 people reported to have side effects when taking Citrus.
Among them, 20 people (11.3%) have Fatigue.

Among these 20 people:

What is the gender of people who have Fatigue when taking Citrus? *

female: 68.42 %
male: 31.58 %

What is the age of people who have Fatigue when taking Citrus? *

What are other drugs people take besides Citrus? *

What are other side effects people have besides Fatigue? *

Anaemia (lack of blood): 9 people, 45.00%
Drowsiness: 9 people, 45.00%
Nausea (feeling of having an urge to vomit): 6 people, 30.00%
Dry Skin: 6 people, 30.00%
Nasopharyngitis (inflammation of the nasopharynx): 5 people, 25.00%
Pain In Extremity: 5 people, 25.00%
Appetite - Decreased (decreased appetite occurs when you have a reduced desire to eat): 5 people, 25.00%
Stress And Anxiety: 5 people, 25.00%
Dizziness: 4 people, 20.00%
Photosensitivity Reaction: 4 people, 20.00%

What are the existing conditions these people have? *

Breast Cancer: 6 people, 30.00%
Ovarian Cancer (cancer of ovary): 6 people, 30.00%
Stress And Anxiety: 4 people, 20.00%
Multiple Myeloma (cancer of the plasma cells): 4 people, 20.00%
Insomnia (sleeplessness): 4 people, 20.00%
Cushing's Syndrome (obesity, a rounded face, increased fat): 2 people, 10.00%
Gout (uric acid crystals building up in the body): 2 people, 10.00%
Hypersensitivity: 2 people, 10.00%
High Blood Pressure: 1 person, 5.00%
Glioblastoma Multiforme (most common and deadliest of malignant primary brain tumours in adults): 1 person, 5.00%

* Approximation only. Some reports may have incomplete information.

Do you take Citrus and have Fatigue?

- Check whether Fatigue is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Citrus:

Citrus (201 reports)

Fatigue treatments and more:

Fatigue (967,543 reports)

Browse all side effects of Citrus:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Fatigue:

Fatigue (4,027 drugs)

Browse all the conditions that are associated with Fatigue:

Fatigue (6,382 conditions)

Related publications that referenced our studies

Peel MM, Cooke M, Lewis-Peel HJ, Lea RA, Moyle W, "A randomized controlled trial of coenzyme Q 10 for fatigue in the late-onset sequelae of poliomyelitis", Complementary therapies in medicine, 2015 Dec .
Peel MM, Cooke M, Lewis-Peel HJ, Lea RA, Moyle W, "A randomized controlled trial of coenzyme Q 10 for fatigue in the late-onset sequelae of poliomyelitis", Complementary therapies in medicine, 2015 Dec .

How the study uses the data?

The study uses data from the FDA. It is based on grapefruit (the active ingredients of Citrus) and Citrus (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.