Clarithromycin and Major depression - a phase IV clinical study of FDA data

Summary:

Major depression is reported as a side effect among people who take Clarithromycin (clarithromycin), especially for people who are female, 50-59 old, have been taking the drug for < 1 month also take Amoxicillin, and have Stress and anxiety.

The phase IV clinical study analyzes which people have Major depression when taking Clarithromycin. It is created by eHealthMe based on reports of 44,030 people who have side effects when taking Clarithromycin from the FDA, and is updated regularly.

What is Clarithromycin?

Clarithromycin has active ingredients of clarithromycin. It is often used in sinusitis. eHealthMe is studying from 45,044 Clarithromycin users. Check the latest studies of Clarithromycin.

What is Major depression?

Major depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings) is found to be associated with 798 drugs and 1,477 conditions by eHealthMe. Check the latest studies of Major depression.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

44,030 people reported to have side effects when taking Clarithromycin.
Among them, 18 people (0.04%) have Major depression.

Could Clarithromycin cause Major depression?

Among these 18 people:

How long have people been on Clarithromycin when they have Major depression? *

What is the gender of people who have Major depression when taking Clarithromycin? *

female: 61.11 %
male: 38.89 %

What is the age of people who have Major depression when taking Clarithromycin? *

What are other drugs people take besides Clarithromycin? *

What are other side effects people have besides Major depression? *

Stress And Anxiety: 13 people, 72.22%
Depression: 7 people, 38.89%
Insomnia (sleeplessness): 6 people, 33.33%
Dyspnea (difficult or laboured breathing): 5 people, 27.78%
Dementia (madness): 5 people, 27.78%
Nausea (feeling of having an urge to vomit): 5 people, 27.78%
Diarrhea: 5 people, 27.78%
Dizziness: 4 people, 22.22%
Gallstones (stone formation by bile component): 4 people, 22.22%
Fatigue (feeling of tiredness): 4 people, 22.22%

What are the existing conditions these people have? *

Stress And Anxiety: 6 people, 33.33%
Asthma: 4 people, 22.22%
Nausea (feeling of having an urge to vomit): 3 people, 16.67%
Helicobacter Infection (helicobacter pylori (h. pylori) infects stomach): 3 people, 16.67%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 2 people, 11.11%
Adrenal Insufficiency (a condition in which the adrenal glands do not produce adequate amounts of steroids): 2 people, 11.11%
Appetite Disorder (abnormal eating habits): 2 people, 11.11%
Bipolar Ii Disorder (characterized by at least one episode of hypomania and at least one episode of major depression): 2 people, 11.11%
Birth Control: 2 people, 11.11%
Blood Testosterone Increased: 2 people, 11.11%

* Approximation only. Some reports may have incomplete information.

Do you take Clarithromycin and have Major depression?

- Check whether Major depression is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Clarithromycin:

Clarithromycin (45,044 reports)

Major depression treatments and more:

Major depression (44,987 reports)

Browse all side effects of Clarithromycin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Major depression:

Major depression (798 drugs)

Browse all the conditions that are associated with Major depression:

Major depression (1,477 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on clarithromycin (the active ingredients of Clarithromycin) and Clarithromycin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.