Claritin and Appendicitis perforated - a phase IV clinical study of FDA data

Summary:

Appendicitis perforated is reported as a side effect among people who take Claritin (loratadine), especially for people who are male, 50-59 old, also take Prednisone, and have Seasonal allergy.

The phase IV clinical study analyzes which people have Appendicitis perforated when taking Claritin. It is created by eHealthMe based on reports of 74,516 people who have side effects when taking Claritin from the FDA, and is updated regularly.

What is Claritin?

Claritin has active ingredients of loratadine. It is often used in allergies. eHealthMe is studying from 77,316 Claritin users. Check the latest studies of Claritin.

What is Appendicitis perforated?

Appendicitis perforated (perforated appendicitis is a condition in which an inflamed appendix bursts) is found to be associated with 363 drugs and 558 conditions by eHealthMe. Check the latest studies of Appendicitis perforated.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 27, 2026

74,516 people reported to have side effects when taking Claritin.
Among them, 21 people (0.03%) have Appendicitis perforated.

Could Claritin cause Appendicitis perforated?

Among these 21 people:

What is the gender of people who have Appendicitis perforated when taking Claritin? *

female: 38.1 %
male: 61.9 %

What is the age of people who have Appendicitis perforated when taking Claritin? *

What are other drugs people take besides Claritin? *

Prednisone: 5 people, 23.81%
Omeprazole: 4 people, 19.05%
Gabapentin: 4 people, 19.05%
Vitamin D3: 4 people, 19.05%
Montelukast Sodium: 3 people, 14.29%
Mirtazapine: 3 people, 14.29%
Metoprolol Succinate: 3 people, 14.29%
Metoclopramide Hydrochloride: 3 people, 14.29%
Metoclopramide: 3 people, 14.29%
Methocarbamol: 3 people, 14.29%

What are other side effects people have besides Appendicitis perforated? *

Drug Ineffective: 10 people, 47.62%
Pneumonia: 5 people, 23.81%
Dyspnea (difficult or laboured breathing): 4 people, 19.05%
Diabetes: 4 people, 19.05%
Weight Fluctuation: 3 people, 14.29%
Bradycardia (abnormally slow heart action): 3 people, 14.29%
Non-Small Cell Lung Cancer Stage Iii: 3 people, 14.29%
Nausea (feeling of having an urge to vomit): 3 people, 14.29%
Nasopharyngitis (inflammation of the nasopharynx): 3 people, 14.29%
Blood Magnesium Decreased: 3 people, 14.29%

What are the existing conditions these people have? *

Seasonal Allergy (allergic condition due to certain season): 12 people, 57.14%
Ulcerative Colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine): 11 people, 52.38%
Immunodeficiency Common Variable: 3 people, 14.29%
Renal Cell Carcinoma (a kidney cancer): 1 person, 4.76%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 1 person, 4.76%
Muscle Aches (muscle pain): 1 person, 4.76%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 1 person, 4.76%
Leukaemia (blood or bone marrow cancer): 1 person, 4.76%
Sinusitis (inflammation of sinus): 1 person, 4.76%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 1 person, 4.76%

* Approximation only. Some reports may have incomplete information.

Do you take Claritin and have Appendicitis perforated?

- Check whether Appendicitis perforated is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Claritin:

Claritin (77,316 reports)

Browse all side effects of Claritin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Appendicitis perforated:

Appendicitis perforated (363 drugs)

Browse all the conditions that are associated with Appendicitis perforated:

Appendicitis perforated (558 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on loratadine (the active ingredients of Claritin) and Claritin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.