Climara and Basal cell carcinoma - a phase IV clinical study of FDA data

Summary:

Basal cell carcinoma is reported as a side effect among people who take Climara (estradiol), especially for people who are female, 60+ old, have been taking the drug for 5 - 10 years also take Loratadine, and have High blood pressure.

The phase IV clinical study analyzes which people have Basal cell carcinoma when taking Climara. It is created by eHealthMe based on reports of 6,607 people who have side effects when taking Climara from the FDA, and is updated regularly.

What is Climara?

Climara has active ingredients of estradiol. It is often used in hormone replacement therapy. eHealthMe is studying from 6,706 Climara users. Check the latest studies of Climara.

What is Basal cell carcinoma?

Basal cell carcinoma (a skin cancer, it rarely metastasizes or kills) is found to be associated with 1,092 drugs and 1,381 conditions by eHealthMe. Check the latest studies of Basal cell carcinoma.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

6,607 people reported to have side effects when taking Climara.
Among them, 16 people (0.24%) have Basal cell carcinoma.

Could Climara cause Basal cell carcinoma?

Among these 16 people:

How long have people been on Climara when they have Basal cell carcinoma? *

What is the gender of people who have Basal cell carcinoma when taking Climara? *

female: 100 %
male: 0.0 %

What is the age of people who have Basal cell carcinoma when taking Climara? *

What are other drugs people take besides Climara? *

What are other side effects people have besides Basal cell carcinoma? *

Stress And Anxiety: 12 people, 75.00%
Breast Disorder: 9 people, 56.25%
Insomnia (sleeplessness): 9 people, 56.25%
Depression: 9 people, 56.25%
Rashes (redness): 9 people, 56.25%
Fall: 9 people, 56.25%
Hot Flush (sudden feelings of heat): 9 people, 56.25%
Ventricular Tachycardia (rapid heartbeat that originates in one of the lower chambers (the ventricles) of the heart): 8 people, 50.00%
Eyelid Ptosis (falling of the upper or lower eyelid): 8 people, 50.00%
Fainting (loss of consciousness and postural tone): 8 people, 50.00%

What are the existing conditions these people have? *

High Blood Pressure: 14 people, 87.50%
Seasonal Allergy (allergic condition due to certain season): 8 people, 50.00%
Osteoporosis (bones weak and more likely to break): 8 people, 50.00%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 6 people, 37.50%
Hot Flush (sudden feelings of heat): 6 people, 37.50%
Depression: 6 people, 37.50%
Breast Cancer: 6 people, 37.50%
Irritable Bowel Syndrome: 5 people, 31.25%
Back Pain: 5 people, 31.25%

* Approximation only. Some reports may have incomplete information.

Do you take Climara and have Basal cell carcinoma?

- Check whether Basal cell carcinoma is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Climara:

Climara (6,706 reports)

Browse all side effects of Climara:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Basal cell carcinoma:

Basal cell carcinoma (1,092 drugs)

Browse all the conditions that are associated with Basal cell carcinoma:

Basal cell carcinoma (1,381 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on estradiol (the active ingredients of Climara) and Climara (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.