Clozapine and Arthropathy - a phase IV clinical study of FDA data

Summary:

Arthropathy is reported as a side effect among people who take Clozapine (clozapine), especially for people who are male, 50-59 old, have been taking the drug for 10+ years also take Folic Acid, and have Rheumatoid arthritis.

The phase IV clinical study analyzes which people have Arthropathy when taking Clozapine. It is created by eHealthMe based on reports of 83,401 people who have side effects when taking Clozapine from the FDA, and is updated regularly.

What is Clozapine?

Clozapine has active ingredients of clozapine. It is often used in schizophrenia. eHealthMe is studying from 83,728 Clozapine users. Check the latest studies of Clozapine.

What is Arthropathy?

Arthropathy is found to be associated with 1,599 drugs and 1,686 conditions by eHealthMe. Check the latest studies of Arthropathy.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 31, 2026

83,401 people reported to have side effects when taking Clozapine.
Among them, 57 people (0.07%) have Arthropathy.

Among these 57 people:

How long have people been on Clozapine when they have Arthropathy? *

What is the gender of people who have Arthropathy when taking Clozapine? *

female: 20 %
male: 80 %

What is the age of people who have Arthropathy when taking Clozapine? *

What are other drugs people take besides Clozapine? *

What are other side effects people have besides Arthropathy? *

Rashes (redness): 32 people, 56.14%
Lung Neoplasm Malignant (cancer tumour of lung): 30 people, 52.63%
Lower Respiratory Tract Infection: 30 people, 52.63%
Abdominal Discomfort: 30 people, 52.63%
Inflammation: 29 people, 50.88%
Overdose: 28 people, 49.12%
Nausea And Vomiting: 19 people, 33.33%
Malaise (a feeling of general discomfort or uneasiness): 16 people, 28.07%
Feeling Abnormal: 15 people, 26.32%
Head Injury: 13 people, 22.81%

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 32 people, 56.14%
Abdominal Discomfort: 30 people, 52.63%
Depression: 30 people, 52.63%
Empty Sella Syndrome (pituitary gland shrinks or becomes flattened): 30 people, 52.63%
Pituitary Tumor: 29 people, 50.88%
Urinary Tract Infection: 8 people, 14.04%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 7 people, 12.28%
Diabetes: 6 people, 10.53%
Reflux Laryngitis (voice disorder caused by backflow of stomach fluids to the throat and voice box area): 6 people, 10.53%
Itching: 6 people, 10.53%

* Approximation only. Some reports may have incomplete information.

Do you take Clozapine and have Arthropathy?

- Check whether Arthropathy is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Clozapine:

Clozapine (83,728 reports)

Arthropathy treatments and more:

Arthropathy (75,984 reports)

Browse all side effects of Clozapine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Arthropathy:

Arthropathy (1,599 drugs)

Browse all the conditions that are associated with Arthropathy:

Arthropathy (1,686 conditions)

Related publications that referenced our studies

Grover S, Sahoo S, "Clozapine induced akathisia: A case report and review of the evidence", Indian journal of pharmacology, 2015 Jan .
Yaylaci S, Yilmaz EU, Guclu E, Kumsar NA, Tamer A, Karabay O, "Clozapine-Induced Febrile Neutropenia and Cellulitis", Turkish journal of emergency medicine, 2014 Mar .
Grover S, Sahoo S, "Clozapine induced akathisia: A case report and review of the evidence", Indian journal of pharmacology, 2015 Jan .
Yaylaci S, Yilmaz EU, Guclu E, Kumsar NA, Tamer A, Karabay O, "Clozapine-Induced Febrile Neutropenia and Cellulitis", Turkish journal of emergency medicine, 2014 Mar .

How the study uses the data?

The study uses data from the FDA. It is based on clozapine (the active ingredients of Clozapine) and Clozapine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.