Clozapine and Maculopathy - a phase IV clinical study of FDA data

Summary:

Maculopathy is reported as a side effect among people who take Clozapine (clozapine), especially for people who are male, 50-59 old, also take Levothyroxine Sodium, and have Epilepsy.

The phase IV clinical study analyzes which people have Maculopathy when taking Clozapine. It is created by eHealthMe based on reports of 83,401 people who have side effects when taking Clozapine from the FDA, and is updated regularly.

What is Clozapine?

Clozapine has active ingredients of clozapine. It is often used in schizophrenia. eHealthMe is studying from 83,728 Clozapine users. Check the latest studies of Clozapine.

What is Maculopathy?

Maculopathy (a condition or disease of the macula, the small spot in the retina where vision is keenest) is found to be associated with 380 drugs and 726 conditions by eHealthMe. Check the latest studies of Maculopathy.

On Jul, 06, 2026

83,401 people reported to have side effects when taking Clozapine.
Among them, 14 people (0.02%) have Maculopathy.

Among these 14 people:

What is the gender of people who have Maculopathy when taking Clozapine? *

female: 30 %
male: 70 %

What is the age of people who have Maculopathy when taking Clozapine? *

What are other drugs people take besides Clozapine? *

Omeprazole: 1 person, 7.14%
Lithium Carbonate: 1 person, 7.14%
Levothyroxine Sodium: 1 person, 7.14%

What are other side effects people have besides Maculopathy? *

Retinopathy (acute damage to the retina of the eye): 7 people, 50.00%
Pigmentation Disorder (disturbances of human skin colour): 4 people, 28.57%
Corneal Disorder: 4 people, 28.57%
Blindness: 4 people, 28.57%
Corneal Pigmentation (colour of cornea): 3 people, 21.43%
Cataract Subcapsular (cataracts that affect the back of the lens): 3 people, 21.43%
Retinogram Abnormal: 2 people, 14.29%
Retinal Degeneration (death of the cells of the retina): 2 people, 14.29%
Macular Pigmentation (pigmented yellow spot near the centre of the retina): 2 people, 14.29%
Lenticular Opacities (swelling and opacity of the entire lens): 2 people, 14.29%

What are the existing conditions these people have? *

High Blood Pressure: 5 people, 35.71%
High Blood Cholesterol: 5 people, 35.71%
Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures): 5 people, 35.71%
Mental Disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability): 3 people, 21.43%
Salivary Hypersecretion (excess saliva secretion): 1 person, 7.14%
Migraine (headache): 1 person, 7.14%
Headache (pain in head): 1 person, 7.14%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 1 person, 7.14%

* Approximation only. Some reports may have incomplete information.

Do you take Clozapine and have Maculopathy?

- Check whether Maculopathy is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Clozapine:

Clozapine (83,728 reports)

Maculopathy treatments and more:

Maculopathy (5,625 reports)

Browse all side effects of Clozapine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Maculopathy:

Maculopathy (380 drugs)

Browse all the conditions that are associated with Maculopathy:

Maculopathy (726 conditions)

Related publications that referenced our studies

Grover S, Sahoo S, "Clozapine induced akathisia: A case report and review of the evidence", Indian journal of pharmacology, 2015 Jan .
Yaylaci S, Yilmaz EU, Guclu E, Kumsar NA, Tamer A, Karabay O, "Clozapine-Induced Febrile Neutropenia and Cellulitis", Turkish journal of emergency medicine, 2014 Mar .
Grover S, Sahoo S, "Clozapine induced akathisia: A case report and review of the evidence", Indian journal of pharmacology, 2015 Jan .
Yaylaci S, Yilmaz EU, Guclu E, Kumsar NA, Tamer A, Karabay O, "Clozapine-Induced Febrile Neutropenia and Cellulitis", Turkish journal of emergency medicine, 2014 Mar .

How the study uses the data?

The study uses data from the FDA. It is based on clozapine (the active ingredients of Clozapine) and Clozapine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.