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Clozapine and Mean cell volume increased - a phase IV clinical study of FDA data

Summary:

Mean cell volume increased is reported as a side effect among people who take Clozapine (clozapine), especially for people who are male, 60+ old, have been taking the drug for 6 - 12 months also take Haloperidol, and have Psychotic disorder.

The phase IV clinical study analyzes which people have Mean cell volume increased when taking Clozapine. It is created by eHealthMe based on reports of 83,401 people who have side effects when taking Clozapine from the FDA, and is updated regularly.

What is Clozapine?

Clozapine has active ingredients of clozapine. It is often used in schizophrenia. eHealthMe is studying from 83,728 Clozapine users. Check the latest studies of Clozapine.

What is Mean cell volume increased?

Mean cell volume increased (more than normal average red blood cell volume) is found to be associated with 455 drugs and 495 conditions by eHealthMe. Check the latest studies of Mean cell volume increased.

On Jul, 14, 2026

83,401 people reported to have side effects when taking Clozapine.
Among them, 96 people (0.12%) have Mean cell volume increased.

Could Clozapine cause Mean cell volume increased?

Among these 96 people:

How long have people been on Clozapine when they have Mean cell volume increased? *

  • < 1 month: 0.0 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 50 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 50 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

What is the gender of people who have Mean cell volume increased when taking Clozapine? *

  • female: 42.55 %
  • male: 57.45 %

What is the age of people who have Mean cell volume increased when taking Clozapine? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 1.15 %
  • 20-29: 9.2 %
  • 30-39: 3.45 %
  • 40-49: 18.39 %
  • 50-59: 24.14 %
  • 60+: 43.68 %

What are other drugs people take besides Clozapine? *

  1. Gliclazide: 4 people, 4.17%
  2. Clonazepam: 4 people, 4.17%
  3. Diazepam: 4 people, 4.17%
  4. Haloperidol: 4 people, 4.17%
  5. Pregabalin: 3 people, 3.12%
  6. Citalopram Hydrobromide: 3 people, 3.12%
  7. Zopiclone: 3 people, 3.12%
  8. Depakote: 2 people, 2.08%
  9. Risperidone: 2 people, 2.08%
  10. Metformin: 2 people, 2.08%

What are other side effects people have besides Mean cell volume increased? *

  1. Red Blood Cell Count Decreased: 57 people, 59.38%
  2. Haemoglobin Decreased: 48 people, 50.00%
  3. Haematocrit Decreased: 39 people, 40.62%
  4. Mean Cell Haemoglobin Concentration Decreased (less concentration of haemoglobin in a given volume of packed red blood cells): 31 people, 32.29%
  5. Monocyte Count Increased: 29 people, 30.21%
  6. Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection): 28 people, 29.17%
  7. Mean Cell Haemoglobin Increased (more than normal haemoglobin per red blood cell in a sample of blood): 27 people, 28.12%
  8. Red Cell Distribution Width Increased: 26 people, 27.08%
  9. Lymphocyte Count Decreased: 22 people, 22.92%
  10. Hospitalisation: 21 people, 21.88%

What are the existing conditions these people have? *

  1. Psychotic Disorder: 10 people, 10.42%
  2. Depression: 4 people, 4.17%
  3. Salivary Hypersecretion (excess saliva secretion): 3 people, 3.12%
  4. Insomnia (sleeplessness): 3 people, 3.12%
  5. Brief Psychotic Disorder, With Postpartum Onset: 2 people, 2.08%
  6. Type 2 Diabetes: 1 person, 1.04%
  7. Polycythaemia (proportion of blood volume that is occupied by red blood cells increases): 1 person, 1.04%
  8. Pain: 1 person, 1.04%
  9. Indigestion: 1 person, 1.04%
  10. Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures): 1 person, 1.04%

* Approximation only. Some reports may have incomplete information.

Do you take Clozapine and have Mean cell volume increased?

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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Clozapine:

Mean cell volume increased treatments and more:

How severe was Mean cell volume increased and when was it recovered:

Expand to all the drugs that have ingredients of clozapine:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Clozapine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Mean cell volume increased:

Browse all the conditions that are associated with Mean cell volume increased:

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on clozapine (the active ingredients of Clozapine) and Clozapine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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