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Clozaril and Unilateral hydronephrosis - a phase IV clinical study of FDA data

Summary:

Unilateral hydronephrosis is reported as a side effect among people who take Clozaril (clozapine), especially for people who are male, 50-59 old, have been taking the drug for 5 - 10 years also take Aripiprazole, and have Constipation.

The phase IV clinical study analyzes which people have Unilateral hydronephrosis when taking Clozaril. It is created by eHealthMe based on reports of 64,938 people who have side effects when taking Clozaril from the FDA, and is updated regularly.

What is Clozaril?

Clozaril has active ingredients of clozapine. It is often used in schizophrenia. eHealthMe is studying from 65,127 Clozaril users. Check the latest studies of Clozaril.

What is Unilateral hydronephrosis?

Unilateral hydronephrosis (kidney stone that causes obstruction of the ureter) is found to be associated with 1,010 drugs and 1,193 conditions by eHealthMe. Check the latest studies of Unilateral hydronephrosis.

On Jul, 15, 2026

64,938 people reported to have side effects when taking Clozaril.
Among them, 43 people (0.07%) have Unilateral hydronephrosis.

Could Clozaril cause Unilateral hydronephrosis?

Among these 43 people:

How long have people been on Clozaril when they have Unilateral hydronephrosis? *

  • < 1 month: 11.11 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 11.11 %
  • 1 - 2 years: 33.33 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 33.33 %
  • 10+ years: 11.11 %

What is the gender of people who have Unilateral hydronephrosis when taking Clozaril? *

  • female: 29.27 %
  • male: 70.73 %

What is the age of people who have Unilateral hydronephrosis when taking Clozaril? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 3.45 %
  • 30-39: 3.45 %
  • 40-49: 34.48 %
  • 50-59: 51.72 %
  • 60+: 6.9 %

What are other drugs people take besides Clozaril? *

  1. Amisulpride: 8 people, 18.60%
  2. Aripiprazole: 8 people, 18.60%
  3. Bisoprolol Fumarate: 7 people, 16.28%
  4. Valproate Sodium: 7 people, 16.28%
  5. Sertraline Hydrochloride: 6 people, 13.95%
  6. Moviprep: 6 people, 13.95%
  7. Levothyroxine Sodium: 6 people, 13.95%
  8. Atorvastatin Calcium: 3 people, 6.98%
  9. Enalapril Maleate: 3 people, 6.98%
  10. Paracetamol: 3 people, 6.98%

What are other side effects people have besides Unilateral hydronephrosis? *

  1. Renal Impairment (severely reduced kidney function): 15 people, 34.88%
  2. Urinary Retention (the inability to completely or partially empty the bladder): 11 people, 25.58%
  3. Urinary Incontinence (inability to control the flow of urine and involuntary urination): 10 people, 23.26%
  4. Nephritis (inflammation of the nephrons in the kidneys): 7 people, 16.28%
  5. Blood Creatinine Increased: 7 people, 16.28%
  6. Orchitis (inflammation of the testes): 7 people, 16.28%
  7. Acute Kidney Failure: 7 people, 16.28%
  8. White Blood Cell Count Decreased: 6 people, 13.95%
  9. Epididymal Infection (infection in testis): 6 people, 13.95%
  10. Constipation: 5 people, 11.63%

What are the existing conditions these people have? *

  1. High Blood Cholesterol: 7 people, 16.28%
  2. Constipation: 7 people, 16.28%
  3. Arrhythmias (irregular heartbeat): 6 people, 13.95%
  4. Blood Thyroid Stimulating Hormone Abnormal: 6 people, 13.95%
  5. Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 6 people, 13.95%
  6. Stress And Anxiety: 4 people, 9.30%
  7. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 6.98%
  8. Migraine (headache): 2 people, 4.65%
  9. Agitation (state of anxiety or nervous excitement): 2 people, 4.65%
  10. Bipolar Disorder (mood disorder): 2 people, 4.65%

* Approximation only. Some reports may have incomplete information.

Do you take Clozaril and have Unilateral hydronephrosis?

- Check whether Unilateral hydronephrosis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Clozaril:

Unilateral hydronephrosis treatments and more:

How severe was Unilateral hydronephrosis and when was it recovered:

Expand to all the drugs that have ingredients of clozapine:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Clozaril:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Unilateral hydronephrosis:

Browse all the conditions that are associated with Unilateral hydronephrosis:

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on clozapine (the active ingredients of Clozaril) and Clozaril (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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