Co-codamol and Depression - a phase IV clinical study of FDA data

Summary:

Depression is reported as a side effect among people who take Co-codamol (acetaminophen; codeine phosphate), especially for people who are female, 60+ old, have been taking the drug for 2 - 5 years also take Gabapentin, and have High blood pressure.

The phase IV clinical study analyzes which people have Depression when taking Co-codamol. It is created by eHealthMe based on reports of 1,873 people who have side effects when taking Co-codamol from the FDA, and is updated regularly.

What is Co-codamol?

Co-codamol has active ingredients of acetaminophen; codeine phosphate. It is often used in pain. eHealthMe is studying from 2,364 Co-codamol users. Check the latest studies of Co-codamol.

What is Depression?

Depression is found to be associated with 3,167 drugs and 4,125 conditions by eHealthMe. Check the latest studies of Depression.

On Jul, 15, 2026

1,873 people reported to have side effects when taking Co-codamol.
Among them, 42 people (2.24%) have Depression.

Among these 42 people:

How long have people been on Co-codamol when they have Depression? *

What is the gender of people who have Depression when taking Co-codamol? *

female: 58.54 %
male: 41.46 %

What is the age of people who have Depression when taking Co-codamol? *

What are other drugs people take besides Co-codamol? *

What are other side effects people have besides Depression? *

Irritability: 11 people, 26.19%
Weakness: 10 people, 23.81%
Mood Swings (an extreme or rapid change in mood): 10 people, 23.81%
Nausea (feeling of having an urge to vomit): 9 people, 21.43%
Confusional State: 9 people, 21.43%
Dyspnea (difficult or laboured breathing): 8 people, 19.05%
Headache (pain in head): 8 people, 19.05%
Malaise (a feeling of general discomfort or uneasiness): 8 people, 19.05%
Weight Decreased: 8 people, 19.05%
Memory Loss: 8 people, 19.05%

What are the existing conditions these people have? *

High Blood Pressure: 7 people, 16.67%
Hiatal Hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm): 4 people, 9.52%
Scoliosis (a medical condition in which a person's spine is curved from side to side): 3 people, 7.14%
Prostatitis (inflammation of the prostate gland): 3 people, 7.14%
Inflammation: 3 people, 7.14%
Headache (pain in head): 3 people, 7.14%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 7.14%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 2 people, 4.76%
Psoriasis (immune-mediated disease that affects the skin): 2 people, 4.76%
Type 2 Diabetes: 1 person, 2.38%

* Approximation only. Some reports may have incomplete information.

Do you take Co-codamol and have Depression?

- Check whether Depression is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Co-codamol:

Co-codamol (2,364 reports)

Depression treatments and more:

Depression (652,144 reports)

How severe was Depression and when was it recovered:

Depression in Co-codamol

Expand to all the drugs that have ingredients of acetaminophen; codeine phosphate:

Depression and drugs with ingredients of acetaminophen; codeine phosphate (1,746 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Co-codamol:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Depression:

Depression (3,167 drugs)

Browse all the conditions that are associated with Depression:

Depression (4,125 conditions)

Related publications that referenced our studies

Pang, T., & Gudi, A., "Chest pain following the use of fluvoxamine in depression", Proceedings of Singapore Healthcare, 2018 Jan .
Pang, T., & Gudi, A., "Chest pain following the use of fluvoxamine in depression", Proceedings of Singapore Healthcare, 2018 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on acetaminophen; codeine phosphate (the active ingredients of Co-codamol) and Co-codamol (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.