Cobamamide and Headache - a phase IV clinical study of FDA data

Summary:

Headache is reported as a side effect among people who take Cobamamide (dibencozide), especially for people who are female, 50-59 old, also take Prednisone, and have Asthma.

The phase IV clinical study analyzes which people have Headache when taking Cobamamide. It is created by eHealthMe based on reports of 1,046 people who have side effects when taking Cobamamide from the FDA, and is updated regularly.

What is Cobamamide?

Cobamamide has active ingredients of dibencozide. eHealthMe is studying from 1,046 Cobamamide users. Check the latest studies of Cobamamide.

What is Headache?

Headache (pain in head) is found to be associated with 3,758 drugs and 5,776 conditions by eHealthMe. Check the latest studies of Headache.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

1,046 people reported to have side effects when taking Cobamamide.
Among them, 93 people (8.89%) have Headache.

Among these 93 people:

What is the gender of people who have Headache when taking Cobamamide? *

female: 89.41 %
male: 10.59 %

What is the age of people who have Headache when taking Cobamamide? *

What are other drugs people take besides Cobamamide? *

What are other side effects people have besides Headache? *

High Blood Pressure: 61 people, 65.59%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 58 people, 62.37%
Asthma: 57 people, 61.29%
Dyspnea (difficult or laboured breathing): 54 people, 58.06%
Sleep Disorder: 54 people, 58.06%
Fibromyalgia (a long-term condition which causes pain all over the body): 53 people, 56.99%
Blood Test Abnormal: 52 people, 55.91%
Sleep Apnea Syndrome: 52 people, 55.91%
Wheezing (a high-pitched whistling sound made while you breath): 51 people, 54.84%
Cardiac Disorder: 50 people, 53.76%

What are the existing conditions these people have? *

Asthma: 28 people, 30.11%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 12 people, 12.90%
Cystic Fibrosis (disease of the secretary glands): 4 people, 4.30%
Ulcerative Colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine): 4 people, 4.30%
Systemic Lupus Erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue): 4 people, 4.30%
Fever: 4 people, 4.30%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 4 people, 4.30%
Osteoporosis (bones weak and more likely to break): 4 people, 4.30%
Urticaria (rash of round, red welts on the skin that itch intensely): 4 people, 4.30%
Fibromyalgia (a long-term condition which causes pain all over the body): 3 people, 3.23%

* Approximation only. Some reports may have incomplete information.

Do you take Cobamamide and have Headache?

- Check whether Headache is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Cobamamide:

Cobamamide (1,046 reports)

Headache treatments and more:

Headache (756,645 reports)

Browse all side effects of Cobamamide:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Headache:

Headache (3,758 drugs)

Browse all the conditions that are associated with Headache:

Headache (5,776 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on dibencozide (the active ingredients of Cobamamide) and Cobamamide (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.