Codeine and Apathy - a phase IV clinical study of FDA data

Summary:

Apathy is reported as a side effect among people who take Codeine (codeine sulfate), especially for people who are female, 60+ old, also take Gravol, and have Short-bowel syndrome.

The phase IV clinical study analyzes which people have Apathy when taking Codeine. It is created by eHealthMe based on reports of 41,713 people who have side effects when taking Codeine from the FDA, and is updated regularly.

What is Codeine?

Codeine has active ingredients of codeine sulfate. It is often used in pain. eHealthMe is studying from 42,342 Codeine users. Check the latest studies of Codeine.

What is Apathy?

Apathy is found to be associated with 803 drugs and 1,164 conditions by eHealthMe. Check the latest studies of Apathy.

On Aug, 10, 2026

41,713 people reported to have side effects when taking Codeine.
Among them, 54 people (0.13%) have Apathy.

Among these 54 people:

What is the gender of people who have Apathy when taking Codeine? *

female: 53.33 %
male: 46.67 %

What is the age of people who have Apathy when taking Codeine? *

What are other drugs people take besides Codeine? *

Acetaminophen: 17 people, 31.48%
Aspirin: 17 people, 31.48%
Jublia: 17 people, 31.48%
Gravol: 17 people, 31.48%
Diclofenac Sodium: 16 people, 29.63%
Magnesium: 15 people, 27.78%
Furosemide: 15 people, 27.78%
Citalopram Hydrobromide: 15 people, 27.78%
Manganese Gluconate: 14 people, 25.93%
Magnesium Citrate: 14 people, 25.93%

What are other side effects people have besides Apathy? *

Depression: 34 people, 62.96%
Drowsiness: 33 people, 61.11%
Fatigue (feeling of tiredness): 32 people, 59.26%
Stress And Anxiety: 28 people, 51.85%
Weight Decreased: 27 people, 50.00%
Nausea (feeling of having an urge to vomit): 27 people, 50.00%
Rashes (redness): 25 people, 46.30%
Nausea And Vomiting: 25 people, 46.30%
Insomnia (sleeplessness): 23 people, 42.59%
Appetite - Decreased (decreased appetite occurs when you have a reduced desire to eat): 22 people, 40.74%

What are the existing conditions these people have? *

Short-Bowel Syndrome (a condition in which the body cannot absorb enough fluids and nutrients because part of the small intestine is missing): 19 people, 35.19%
Premenstrual Syndrome: 17 people, 31.48%
Type 2 Diabetes: 11 people, 20.37%
Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures): 11 people, 20.37%
Morganella Infection (infection by morganella morganii bacteria): 11 people, 20.37%
Depression: 8 people, 14.81%
Sciatica (a set of symptoms including pain caused by general compression or irritation of one of five spinal nerve roots of each sciatic nerve): 5 people, 9.26%
Restless Leg Syndrome (a powerful urge to move your legs): 5 people, 9.26%
Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters): 5 people, 9.26%
Oedema (fluid collection in tissue): 3 people, 5.56%

* Approximation only. Some reports may have incomplete information.

Do you take Codeine and have Apathy?

- Check whether Apathy is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Codeine:

Codeine (42,342 reports)

Apathy treatments and more:

Apathy (16,905 reports)

Browse all side effects of Codeine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Apathy:

Apathy (803 drugs)

Browse all the conditions that are associated with Apathy:

Apathy (1,164 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on codeine sulfate (the active ingredients of Codeine) and Codeine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.