Codeine and Appendicitis perforated - a phase IV clinical study of FDA data

Summary:

Appendicitis perforated is reported as a side effect among people who take Codeine (codeine sulfate), especially for people who are male, 60+ old, also take Nystatin, and have Blepharitis.

The phase IV clinical study analyzes which people have Appendicitis perforated when taking Codeine. It is created by eHealthMe based on reports of 41,713 people who have side effects when taking Codeine from the FDA, and is updated regularly.

What is Codeine?

Codeine has active ingredients of codeine sulfate. It is often used in pain. eHealthMe is studying from 42,341 Codeine users. Check the latest studies of Codeine.

What is Appendicitis perforated?

Appendicitis perforated (perforated appendicitis is a condition in which an inflamed appendix bursts) is found to be associated with 418 drugs and 543 conditions by eHealthMe. Check the latest studies of Appendicitis perforated.

On Dec, 26, 2025

41,713 people reported to have side effects when taking Codeine.
Among them, 11 people (0.03%) have Appendicitis perforated.

Could Codeine cause Appendicitis perforated?

Among these 11 people:

What is the gender of people who have Appendicitis perforated when taking Codeine? *

female: 36.36 %
male: 63.64 %

What is the age of people who have Appendicitis perforated when taking Codeine? *

What are other drugs people take besides Codeine? *

Aspirin: 5 people, 45.45%
Nitroglycerin: 5 people, 45.45%
Cabozantinib: 5 people, 45.45%
Gabapentin: 5 people, 45.45%
Isosorbide Mononitrate: 5 people, 45.45%
Losartan: 5 people, 45.45%
Nystatin: 5 people, 45.45%
Zoladex: 3 people, 27.27%
Zoledronic Acid: 3 people, 27.27%
Humira: 2 people, 18.18%

What are other side effects people have besides Appendicitis perforated? *

Immune System Disorder: 2 people, 18.18%
Insomnia (sleeplessness): 2 people, 18.18%
Dyspnea (difficult or laboured breathing): 2 people, 18.18%
Injection Site Extravasation (flow of (blood or lymph) from injection site): 2 people, 18.18%
Injection Site Mass: 2 people, 18.18%
Aggression: 2 people, 18.18%
Intestinal Resection: 1 person, 9.09%
Injection Site Haemorrhage (bleeding from injection site): 1 person, 9.09%
Overdose: 1 person, 9.09%
Skin - Clammy: 1 person, 9.09%

What are the existing conditions these people have? *

Palmar-Plantar Erythrodysaesthesia Syndrome (hand-foot syndrome): 4 people, 36.36%
Oral Candidiasis (fungal infection of mouth): 4 people, 36.36%
Myocardial Ischaemia (the blood flow through one or more of the blood vessels that lead to heart (coronary arteries) is decreased): 4 people, 36.36%
Mouth Ulcers: 4 people, 36.36%
High Blood Pressure: 4 people, 36.36%
Fungal Infection: 4 people, 36.36%
Blepharitis (chronic inflammation of the eyelid): 4 people, 36.36%
Metastases To Bone (cancer spreads to bone): 3 people, 27.27%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 2 people, 18.18%
Nausea (feeling of having an urge to vomit): 1 person, 9.09%

* Approximation only. Some reports may have incomplete information.

Do you take Codeine and have Appendicitis perforated?

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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Codeine:

Codeine (42,341 reports)

Browse all side effects of Codeine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Appendicitis perforated:

Appendicitis perforated (418 drugs)

Browse all the conditions that are associated with Appendicitis perforated:

Appendicitis perforated (543 conditions)

Drugs similar to Codeine and Appendicitis perforated :

How the study uses the data?

The study uses data from the FDA. It is based on codeine sulfate (the active ingredients of Codeine) and Codeine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.